Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 576324..576802 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name VapD Uniprot ID Q4QN95
Locus tag DQL18_RS02915 Protein ID WP_011272058.1
Coordinates 576524..576802 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q4QN94
Locus tag DQL18_RS02910 Protein ID WP_011272059.1
Coordinates 576324..576515 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS02885 571919..572551 + 633 WP_050948790.1 dTMP kinase -
DQL18_RS02890 572548..573528 + 981 WP_105905481.1 DNA polymerase III subunit delta' -
DQL18_RS02895 573567..574349 + 783 WP_105905480.1 YchF/TatD family DNA exonuclease -
DQL18_RS02900 574376..574900 + 525 WP_005669286.1 DUF1523 family protein -
DQL18_RS02905 574951..576252 + 1302 WP_111722478.1 hemolysin family protein -
DQL18_RS02910 576324..576515 + 192 WP_011272059.1 DUF5397 family protein Antitoxin
DQL18_RS02915 576524..576802 + 279 WP_011272058.1 virulence-associated protein VapD Toxin
DQL18_RS02920 576895..577425 + 531 WP_005649345.1 hypothetical protein -
DQL18_RS02925 577497..578996 + 1500 WP_011272056.1 fused PTS fructose transporter subunit IIA/HPr protein -
DQL18_RS02930 578998..579939 + 942 WP_011272055.1 1-phosphofructokinase -
DQL18_RS02935 579941..581611 + 1671 WP_105905478.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10647.08 Da        Isoelectric Point: 4.9670

>T292646 WP_011272058.1 NZ_LS483486:576524-576802 [Haemophilus influenzae]
MYAIAFDLVVKDTQDYHPKGVQEAYTDIGAVLAKFGFVRTQGSLYTNMNEDMANLFQAMNALKQLAWISQSVRDIRAFRI
EQWSDFTDFIRN

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7073.06 Da        Isoelectric Point: 3.8431

>AT292646 WP_011272059.1 NZ_LS483486:576324-576515 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSYLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6ZI0
PDB 6ZN8
PDB 6ZI1

Antitoxin

Source ID Structure
PDB 6ZN8
AlphaFold DB Q4QN94

References