Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 384848..385319 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name toxT Uniprot ID A0A806DTA9
Locus tag DQL18_RS01905 Protein ID WP_005654546.1
Coordinates 384848..385030 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQL18_RS01910 Protein ID WP_005650837.1
Coordinates 385023..385319 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS01900 381444..384587 + 3144 WP_111722589.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQL18_RS01905 384848..385030 + 183 WP_005654546.1 shikimate 5-dehydrogenase Toxin
DQL18_RS01910 385023..385319 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQL18_RS01915 385480..387396 + 1917 WP_105905590.1 ABC transporter ATP-binding protein -
DQL18_RS01920 387406..387942 + 537 WP_038439524.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQL18_RS01925 387958..388509 + 552 WP_038439523.1 Sua5/YciO/YrdC/YwlC family protein -
DQL18_RS01930 388513..389319 + 807 WP_105905591.1 shikimate dehydrogenase -
DQL18_RS01935 389331..390083 + 753 WP_011272149.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7318.33 Da        Isoelectric Point: 6.3057

>T292645 WP_005654546.1 NZ_LS483486:384848-385030 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Download         Length: 183 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292645 WP_005650837.1 NZ_LS483486:385023-385319 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DTA9

Antitoxin

Source ID Structure

References