Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/YafQ-RelB
Location 330960..331564 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name relE Uniprot ID A0A0K9L7B7
Locus tag DQL18_RS01660 Protein ID WP_005692344.1
Coordinates 330960..331268 (-) Length 103 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q4QMK8
Locus tag DQL18_RS01665 Protein ID WP_005692346.1
Coordinates 331268..331564 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS01650 326071..327369 - 1299 WP_105897869.1 trigger factor -
DQL18_RS01655 327670..330903 + 3234 WP_111722470.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQL18_RS01660 330960..331268 - 309 WP_005692344.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
DQL18_RS01665 331268..331564 - 297 WP_005692346.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQL18_RS01670 331684..332538 - 855 WP_105905582.1 DUF3298 domain-containing protein -
DQL18_RS01675 332557..334416 - 1860 WP_105905583.1 selenocysteine-specific translation elongation factor -
DQL18_RS01680 334413..335798 - 1386 WP_105886415.1 L-seryl-tRNA(Sec) selenium transferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(8-98)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(5-93)


Sequences

Toxin        


Download         Length: 103 a.a.        Molecular weight: 11974.77 Da        Isoelectric Point: 8.4339

>T292643 WP_005692344.1 NZ_LS483486:c331268-330960 [Haemophilus influenzae]
MSEEKPLKVSYSKQFVRDLTDLAKRSPNVLIGSKYITAIYCLLNRLPLPENYQDHALVGEWKGYRDCYIQGNLVLIYQYV
IRDEFDELKFSRLNTHSQTALK

Download         Length: 309 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11003.27 Da        Isoelectric Point: 4.2845

>AT292643 WP_005692346.1 NZ_LS483486:c331564-331268 [Haemophilus influenzae]
MALTNSSISFRTVEQTKSEAYQVIEQYGLTPSQVFNMFLAQIAKTRSIPIDLNYLRPNKETLAAIDELDSGNAESFFIEA
SENYSAEEFTKRILNGGQ

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0K9L7B7

Antitoxin

Source ID Structure
AlphaFold DB Q4QMK8

References