Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 46502..47133 Replicon chromosome
Accession NZ_LS483486
Organism Haemophilus influenzae strain NCTC12194

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DQL18_RS00235 Protein ID WP_105905411.1
Coordinates 46735..47133 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag DQL18_RS00230 Protein ID WP_005648011.1
Coordinates 46502..46735 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL18_RS00205 41982..43184 - 1203 WP_011272308.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
DQL18_RS00210 43347..44012 + 666 WP_013526173.1 DNA repair protein RadC -
DQL18_RS00215 44226..44462 + 237 WP_005542826.1 50S ribosomal protein L28 -
DQL18_RS00220 44474..44644 + 171 WP_005613503.1 50S ribosomal protein L33 -
DQL18_RS00225 44991..46355 + 1365 WP_005651563.1 diaminobutyrate--2-oxoglutarate transaminase -
DQL18_RS00230 46502..46735 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
DQL18_RS00235 46735..47133 + 399 WP_105905411.1 tRNA(fMet)-specific endonuclease VapC Toxin
DQL18_RS00240 47153..48688 + 1536 WP_011272306.1 L-2,4-diaminobutyrate decarboxylase -
DQL18_RS00245 48920..49735 + 816 WP_011272305.1 DNA-formamidopyrimidine glycosylase -
DQL18_RS00250 49809..50831 - 1023 WP_005693292.1 outer membrane-stress sensor serine endopeptidase DegS -
DQL18_RS00255 50832..51950 - 1119 WP_011272304.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15087.40 Da        Isoelectric Point: 8.0514

>T292642 WP_105905411.1 NZ_LS483486:46735-47133 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILASNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT292642 WP_005648011.1 NZ_LS483486:46502-46735 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References