Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1141294..1142852 Replicon chromosome
Accession NZ_LS483485
Organism Aggregatibacter aphrophilus strain NCTC11096

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DQL22_RS05785 Protein ID WP_111300312.1
Coordinates 1141294..1142574 (-) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DQL22_RS05790 Protein ID WP_111300310.1
Coordinates 1142574..1142852 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL22_RS05765 1136820..1137266 + 447 WP_109843040.1 DNA polymerase III subunit chi -
DQL22_RS05770 1137344..1137649 + 306 WP_111300318.1 N(4)-acetylcytidine aminohydrolase -
DQL22_RS05775 1137656..1138318 + 663 WP_111300316.1 hypothetical protein -
DQL22_RS05780 1138346..1141210 + 2865 WP_111300314.1 valine--tRNA ligase -
DQL22_RS05785 1141294..1142574 - 1281 WP_111300312.1 type II toxin-antitoxin system HipA family toxin Toxin
DQL22_RS05790 1142574..1142852 - 279 WP_111300310.1 helix-turn-helix domain-containing protein Antitoxin
DQL22_RS05795 1143007..1144062 - 1056 WP_111300308.1 ABC transporter substrate-binding protein -
DQL22_RS05800 1144314..1145828 - 1515 WP_109843034.1 DHA2 family efflux MFS transporter permease subunit -
DQL22_RS05805 1145841..1147001 - 1161 WP_005703922.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
DQL22_RS05810 1147192..1147674 + 483 WP_109843033.1 DNA starvation/stationary phase protection protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(148-391)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49099.36 Da        Isoelectric Point: 7.7249

>T292641 WP_111300312.1 NZ_LS483485:c1142574-1141294 [Aggregatibacter aphrophilus]
MSNSILNVAMNGLLVGEWRKLTSGASEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKEVENVLRNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLCGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQPRHIFNTAKLAGLAKETVEDVLHEISALYPRVSE
INTHGLPDEIVEPILMGLEMQMKKIS

Download         Length: 1281 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10341.78 Da        Isoelectric Point: 4.8483

>AT292641 WP_111300310.1 NZ_LS483485:c1142852-1142574 [Aggregatibacter aphrophilus]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTALSIK
EPAATYDDDEAW

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References