Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 2246010..2246524 Replicon chromosome
Accession NZ_LS483484
Organism Staphylococcus aureus strain NCTC13277

Toxin (Protein)


Gene name TsdT Uniprot ID A0A7U7IDH9
Locus tag DQL77_RS11560 Protein ID WP_000581791.1
Coordinates 2246010..2246219 (-) Length 70 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A0D1GBN9
Locus tag DQL77_RS11565 Protein ID WP_000138934.1
Coordinates 2246231..2246524 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL77_RS11540 2241899..2242969 - 1071 WP_000159639.1 D-alanine--D-alanine ligase -
DQL77_RS11545 2243287..2244489 + 1203 WP_001109939.1 rod shape-determining protein RodA -
DQL77_RS11550 2244650..2245333 - 684 Protein_2149 transposase -
DQL77_RS11555 2245745..2245882 - 138 WP_000828354.1 hypothetical protein -
DQL77_RS11560 2246010..2246219 - 210 WP_000581791.1 heavy-metal-associated domain-containing protein Toxin
DQL77_RS11565 2246231..2246524 - 294 WP_000138934.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL77_RS11570 2246690..2248174 + 1485 WP_000571560.1 cardiolipin synthase -
DQL77_RS11575 2248202..2248849 + 648 WP_001187612.1 HD domain-containing protein -
DQL77_RS11585 2249006..2249305 + 300 WP_001793952.1 hypothetical protein -
DQL77_RS11590 2249462..2250334 - 873 WP_000730708.1 membrane protein insertase YidC -
DQL77_RS11595 2250420..2251061 - 642 WP_000483150.1 thiamine phosphate synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(23-66)

Antitoxin

Metal-sensitive transcriptional repressor

(3-95)


Sequences

Toxin        


Download         Length: 70 a.a.        Molecular weight: 7826.83 Da        Isoelectric Point: 4.1008

>T292635 WP_000581791.1 NZ_LS483484:c2246219-2246010 [Staphylococcus aureus]
MIHQNTIYTAGIETEEQVSQLTERISNMIGVHQVIINIIDGQVTVAYETPANLNSIEKEIYDEGYKIVF

Download         Length: 210 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11185.77 Da        Isoelectric Point: 6.2243

>AT292635 WP_000138934.1 NZ_LS483484:c2246524-2246231 [Staphylococcus aureus]
MTEQDNAHHSEQIKTNLKSRLNRIEGQVRAINRMIEEDVYCDDVLTQIRATRSALNSVATKLLEQHMKSCIMNKVNQGAQ
EEAMEELLVTFQKLIKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U7IDH9

Antitoxin

Source ID Structure
AlphaFold DB A0A0D1GBN9

References