Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsaAT/-
Location 898299..898776 Replicon chromosome
Accession NZ_LS483484
Organism Staphylococcus aureus strain NCTC13277

Toxin (Protein)


Gene name TsaT Uniprot ID T1Y7S2
Locus tag DQL77_RS04445 Protein ID WP_000052076.1
Coordinates 898299..898487 (-) Length 63 a.a.

Antitoxin (Protein)


Gene name TsaA Uniprot ID T1Y6P8
Locus tag DQL77_RS04450 Protein ID WP_001059690.1
Coordinates 898516..898776 (-) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL77_RS04415 894252..894809 + 558 WP_000824491.1 hypothetical protein -
DQL77_RS04420 895150..895836 + 687 WP_001643461.1 thermonuclease family protein -
DQL77_RS04425 896193..896393 + 201 WP_001059082.1 cold-shock protein -
DQL77_RS04430 896890..897108 - 219 WP_000005879.1 hypothetical protein -
DQL77_RS04435 897170..897454 - 285 WP_001004401.1 hypothetical protein -
DQL77_RS04440 897542..898111 - 570 WP_001106663.1 hypothetical protein -
DQL77_RS04445 898299..898487 - 189 WP_000052076.1 hypothetical protein Toxin
DQL77_RS04450 898516..898776 - 261 WP_001059690.1 hypothetical protein Antitoxin
DQL77_RS04455 899117..899320 + 204 WP_000145163.1 sterile alpha motif-like domain-containing protein -
DQL77_RS04460 899317..899553 - 237 WP_000368687.1 hypothetical protein -
DQL77_RS04465 899778..900359 + 582 WP_001140696.1 phosphoglycerate mutase family protein -
DQL77_RS04470 900432..901049 - 618 WP_000255545.1 LysE/ArgO family amino acid transporter -
DQL77_RS04475 901205..901699 - 495 WP_000569884.1 GNAT family N-acetyltransferase -
DQL77_RS04480 902098..902520 - 423 WP_000974455.1 organic hydroperoxide resistance protein -
DQL77_RS04485 902668..903384 + 717 WP_000150036.1 type I 3-dehydroquinate dehydratase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 63 a.a.        Molecular weight: 7142.82 Da        Isoelectric Point: 9.9971

>T292624 WP_000052076.1 NZ_LS483484:c898487-898299 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Download         Length: 189 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9940.09 Da        Isoelectric Point: 4.0624

>AT292624 WP_001059690.1 NZ_LS483484:c898776-898516 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYSFIG

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0VP18

Antitoxin

Source ID Structure
AlphaFold DB A0A0E0VN56

References