292622

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 982498..983015 Replicon chromosome
Accession NZ_LS483482
Organism Staphylococcus lugdunensis strain NCTC12217

Toxin (Protein)


Gene name mazF Uniprot ID A0A853V3R6
Locus tag DQL46_RS04575 Protein ID WP_002461192.1
Coordinates 982665..983015 (+) Length 117 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID A0A853V233
Locus tag DQL46_RS04570 Protein ID WP_002461193.1
Coordinates 982498..982668 (+) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL46_RS04545 978323..978805 + 483 WP_002492078.1 PH domain-containing protein -
DQL46_RS04550 978798..980312 + 1515 WP_080606540.1 PH domain-containing protein -
DQL46_RS04555 980299..980811 + 513 WP_002478976.1 PH domain-containing protein -
DQL46_RS04560 980823..981215 + 393 WP_002461196.1 holo-ACP synthase -
DQL46_RS04565 981263..982411 + 1149 WP_070647975.1 alanine racemase -
DQL46_RS04570 982498..982668 + 171 WP_002461193.1 hypothetical protein Antitoxin
DQL46_RS04575 982665..983015 + 351 WP_002461192.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
DQL46_RS04580 983449..984450 + 1002 WP_002461191.1 PP2C family protein-serine/threonine phosphatase -
DQL46_RS04585 984541..984867 + 327 WP_002461190.1 anti-sigma factor antagonist -
DQL46_RS04590 984869..985348 + 480 WP_012990787.1 anti-sigma B factor RsbW -
DQL46_RS04595 985323..986093 + 771 WP_002461188.1 RNA polymerase sigma factor SigB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 13079.20 Da        Isoelectric Point: 9.9784

>T292622 WP_002461192.1 NZ_LS483482:982665-983015 [Staphylococcus lugdunensis]
MIRRGDVYLADLSPVQGSEQGGVRPVVIIQNDTGNKYSPTVIVAAITGRINKAKIPTHVEIGKKKYKLDKDSVILLEQIR
TLDKKRLKEKLTYLSEDKMKEVDHALDISLGLHNYH

Download         Length: 351 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6327.92 Da        Isoelectric Point: 4.0115

>AT292622 WP_002461193.1 NZ_LS483482:982498-982668 [Staphylococcus lugdunensis]
MLTFNQNRSHSLEQSLKEGYAQMADLNLSLATEAFPIECEACDCNETYLTSNHQSE

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853V3R6

Antitoxin

Source ID Structure
AlphaFold DB A0A853V233

References