Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) TsdAT/-
Location 971096..971614 Replicon chromosome
Accession NZ_LS483482
Organism Staphylococcus lugdunensis strain NCTC12217

Toxin (Protein)


Gene name TsdT Uniprot ID -
Locus tag DQL46_RS04515 Protein ID WP_002478973.1
Coordinates 971402..971614 (+) Length 71 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID A0A853V130
Locus tag DQL46_RS04510 Protein ID WP_002492098.1
Coordinates 971096..971389 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL46_RS04490 966702..967340 + 639 WP_002461213.1 thiamine phosphate synthase -
DQL46_RS04495 967430..968305 + 876 WP_002461212.1 membrane protein insertase YidC -
DQL46_RS04500 968683..969324 - 642 WP_070647978.1 HD domain-containing protein -
DQL46_RS04505 969446..970930 - 1485 WP_070647977.1 cardiolipin synthase -
DQL46_RS04510 971096..971389 + 294 WP_002492098.1 copper-sensing transcriptional repressor CsoR Antitoxin
DQL46_RS04515 971402..971614 + 213 WP_002478973.1 heavy-metal-associated domain-containing protein Toxin
DQL46_RS04520 971705..971842 + 138 WP_002461206.1 hypothetical protein -
DQL46_RS04525 972256..973446 - 1191 WP_002461205.1 rod shape-determining protein RodA -
DQL46_RS04530 973802..974872 + 1071 WP_002461204.1 D-alanine--D-alanine ligase -
DQL46_RS04535 974890..976248 + 1359 WP_062077884.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Heavy metal-associated domain, HMA

(19-66)

Antitoxin

Metal-sensitive transcriptional repressor

(14-90)


Sequences

Toxin        


Download         Length: 71 a.a.        Molecular weight: 8070.03 Da        Isoelectric Point: 3.9947

>T292621 WP_002478973.1 NZ_LS483482:971402-971614 [Staphylococcus lugdunensis]
VEKRLIYITNVTSEDDLENLRTRLLEMIGVNEVVINFDERAVNVTFETPTNLNALEKEIYDAGYHAIDDL

Download         Length: 213 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11177.85 Da        Isoelectric Point: 6.6367

>AT292621 WP_002492098.1 NZ_LS483482:971096-971389 [Staphylococcus lugdunensis]
MNEQDHAHHSKIVKANLKSRLNRIEGQVRAINRMVEDDVYCDDVLTQIRATRSALTSVATKLLEHHMKSCIMDKINDGQE
VEAMEELLVTFQKMLKD

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A853V130

References