292618

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 580007..580484 Replicon chromosome
Accession NZ_LS483480
Organism Haemophilus influenzae strain NCTC13377

Toxin (Protein)


Gene name VapD Uniprot ID -
Locus tag DQL19_RS09645 Protein ID WP_015701676.1
Coordinates 580347..580484 (+) Length 46 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID A0A0M1GIA6
Locus tag DQL19_RS02970 Protein ID WP_005649350.1
Coordinates 580007..580198 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL19_RS02945 575586..576218 + 633 WP_041175109.1 dTMP kinase -
DQL19_RS02950 576215..577198 + 984 WP_015701679.1 DNA polymerase III subunit delta' -
DQL19_RS02955 577253..578035 + 783 WP_005649353.1 YchF/TatD family DNA exonuclease -
DQL19_RS02960 578062..578586 + 525 WP_077643688.1 DUF1523 family protein -
DQL19_RS02965 578637..579935 + 1299 WP_077643689.1 hemolysin family protein -
DQL19_RS02970 580007..580198 + 192 WP_005649350.1 DUF5397 domain-containing protein Antitoxin
DQL19_RS09645 580347..580484 + 138 WP_015701676.1 virulence-associated protein VapD Toxin
DQL19_RS02980 580577..581107 + 531 WP_005686915.1 hypothetical protein -
DQL19_RS02985 581179..582678 + 1500 WP_015701675.1 fused PTS fructose transporter subunit IIA/HPr protein -
DQL19_RS02990 582680..583651 + 972 WP_015701674.1 1-phosphofructokinase -
DQL19_RS02995 583623..585293 + 1671 WP_015701673.1 fructose-specific PTS transporter subunit EIIC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Protein of unknown function DUF5397

(1-63)


Sequences

Toxin        


Download         Length: 46 a.a.        Molecular weight: 5422.16 Da        Isoelectric Point: 4.7105

>T292618 WP_015701676.1 NZ_LS483480:580347-580484 [Haemophilus influenzae]
MNEDMANLFQAMNALKQLAWISQSVRDIRAFRIEQWSDFTDFIRN

Download         Length: 138 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7047.02 Da        Isoelectric Point: 3.9930

>AT292618 WP_005649350.1 NZ_LS483480:580007-580198 [Haemophilus influenzae]
MELRQQIPTGCIKQFGQFGVPYVVGEVAEFLPDGDVLVNITLLQSGEKDIYRLSHLLEDPEAE

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0M1GIA6

References