Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 358344..358992 Replicon chromosome
Accession NZ_LS483480
Organism Haemophilus influenzae strain NCTC13377

Toxin (Protein)


Gene name toxT Uniprot ID -
Locus tag DQL19_RS01800 Protein ID WP_077643740.1
Coordinates 358344..358703 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQL19_RS01805 Protein ID WP_005650837.1
Coordinates 358696..358992 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL19_RS01795 355126..358074 + 2949 WP_111742157.1 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQL19_RS01800 358344..358703 + 360 WP_077643740.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL19_RS01805 358696..358992 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQL19_RS01810 359149..361065 + 1917 WP_077643739.1 ABC transporter ATP-binding protein -
DQL19_RS01815 361075..361611 + 537 WP_077643738.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQL19_RS01820 361627..362178 + 552 WP_077643737.1 Sua5/YciO/YrdC/YwlC family protein -
DQL19_RS01825 362182..362988 + 807 WP_077643736.1 shikimate dehydrogenase -
DQL19_RS01830 363202..363765 + 564 WP_077643735.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14287.65 Da        Isoelectric Point: 10.1408

>T292617 WP_077643740.1 NZ_LS483480:358344-358703 [Haemophilus influenzae]
MYEILLYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292617 WP_005650837.1 NZ_LS483480:358696-358992 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References