Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-DnaT
Location 76641..77175 Replicon chromosome
Accession NZ_LS483480
Organism Haemophilus influenzae strain NCTC13377

Toxin (Protein)


Gene name relE Uniprot ID Q849T7
Locus tag DQL19_RS00395 Protein ID WP_015701940.1
Coordinates 76885..77175 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A2X4XNI1
Locus tag DQL19_RS00390 Protein ID WP_015701941.1
Coordinates 76641..76895 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL19_RS00355 72225..72485 + 261 WP_005651528.1 hypothetical protein -
DQL19_RS00360 72515..72880 + 366 WP_015701945.1 endonuclease domain-containing protein -
DQL19_RS00365 73217..75283 + 2067 WP_015701944.1 glycine--tRNA ligase subunit beta -
DQL19_RS00375 75803..76111 + 309 Protein_71 P2 family phage major capsid protein -
DQL19_RS00380 76111..76335 + 225 WP_015701942.1 hypothetical protein -
DQL19_RS00385 76344..76550 + 207 WP_041175054.1 hypothetical protein -
DQL19_RS00390 76641..76895 + 255 WP_015701941.1 stability protein StbD Antitoxin
DQL19_RS00395 76885..77175 + 291 WP_015701940.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL19_RS09610 77632..77769 + 138 WP_172451690.1 hypothetical protein -
DQL19_RS00405 78237..79271 - 1035 WP_015701939.1 DNA polymerase III subunit delta -
DQL19_RS00410 79271..79774 - 504 WP_015701938.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11496.44 Da        Isoelectric Point: 10.6484

>T292614 WP_015701940.1 NZ_LS483480:76885-77175 [Haemophilus influenzae]
MTYKLIFDKRALKEWNKLGETLRQQFKNKLAERMINPRIQADKLKGENDLYKIKLRSAGYRLVYQVRDQEITIIVVSIGK
RERLEVYKTAEQRTAH

Download         Length: 291 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9449.81 Da        Isoelectric Point: 4.0737

>AT292614 WP_015701941.1 NZ_LS483480:76641-76895 [Haemophilus influenzae]
MALHQILAEQAASITDLKRNPMGVIQESESGIVAILNRNQPAFYCITPELFSHMQELIEDLELSRMANERLATLEPVEVD
LNDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q849T7

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XNI1

References