292613

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 48035..48666 Replicon chromosome
Accession NZ_LS483480
Organism Haemophilus influenzae strain NCTC13377

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag DQL19_RS00245 Protein ID WP_005651560.1
Coordinates 48268..48666 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A2X4XKC3
Locus tag DQL19_RS00240 Protein ID WP_015701961.1
Coordinates 48035..48268 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL19_RS00215 43515..44717 - 1203 WP_015701964.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
DQL19_RS00220 44880..45545 + 666 WP_013527272.1 DNA repair protein RadC -
DQL19_RS00225 45759..45995 + 237 WP_005542826.1 50S ribosomal protein L28 -
DQL19_RS00230 46007..46177 + 171 WP_005613503.1 50S ribosomal protein L33 -
DQL19_RS00235 46524..47888 + 1365 WP_015701962.1 diaminobutyrate--2-oxoglutarate transaminase -
DQL19_RS00240 48035..48268 + 234 WP_015701961.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
DQL19_RS00245 48268..48666 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
DQL19_RS00250 48686..50221 + 1536 WP_015701960.1 L-2,4-diaminobutyrate decarboxylase -
DQL19_RS00255 50452..51267 + 816 WP_015701959.1 DNA-formamidopyrimidine glycosylase -
DQL19_RS00260 51341..52363 - 1023 WP_015701958.1 outer membrane-stress sensor serine endopeptidase DegS -
DQL19_RS00265 52364..53482 - 1119 WP_015701957.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-55)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T292613 WP_005651560.1 NZ_LS483480:48268-48666 [Haemophilus influenzae]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8911.01 Da        Isoelectric Point: 4.4013

>AT292613 WP_015701961.1 NZ_LS483480:48035-48268 [Haemophilus influenzae]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQTVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4XKC3

References