Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PumAB/upstrm_HI1419-dnstrm_HI1420
Location 462430..463004 Replicon chromosome
Accession NZ_LS483473
Organism Pasteurella multocida strain NCTC10382

Toxin (Protein)


Gene name PumA Uniprot ID -
Locus tag DQL67_RS02190 Protein ID WP_061406134.1
Coordinates 462430..462714 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name PumB Uniprot ID -
Locus tag DQL67_RS02195 Protein ID WP_061406133.1
Coordinates 462711..463004 (+) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL67_RS02170 458223..459812 - 1590 WP_081106270.1 AAA family ATPase -
DQL67_RS02175 460097..460648 - 552 WP_196766247.1 NERD domain-containing protein -
DQL67_RS02180 460792..461151 + 360 WP_095261631.1 DUF3418 domain-containing protein -
DQL67_RS02190 462430..462714 + 285 WP_061406134.1 hypothetical protein Toxin
DQL67_RS02195 462711..463004 + 294 WP_061406133.1 putative addiction module antidote protein Antitoxin
DQL67_RS02200 463407..464084 - 678 WP_005726756.1 3-keto-L-gulonate-6-phosphate decarboxylase UlaD -
DQL67_RS02205 464102..464569 - 468 WP_005726755.1 PTS sugar transporter subunit IIA -
DQL67_RS02210 464614..466404 - 1791 WP_005726754.1 PTS ascorbate-specific subunit IIBC -
DQL67_RS02215 466754..467845 + 1092 WP_005751571.1 L-ascorbate 6-phosphate lactonase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(4-87)

Antitoxin

Uncharacterized protein HI1420

(7-92)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10667.40 Da        Isoelectric Point: 10.2297

>T292611 WP_061406134.1 NZ_LS483473:462430-462714 [Pasteurella multocida]
VGRLKEVKILSAKSAVLARINKAMNGNFGDHKSIGNGLYEMRIIKGSGYRVYYGQYREVTYLLICGGDKSTQKSDIVKAR
ELWKEIKQQEEVKV

Download         Length: 285 bp

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10947.88 Da        Isoelectric Point: 8.9149

>AT292611 WP_061406133.1 NZ_LS483473:462711-463004 [Pasteurella multocida]
MSKKKIKLKLFDIAEHLDSEEMIAAYLSEVLETCDTNEFISALSDVVRAKGMTELAAKTGLRRESLYKTLSYGSKPRFDT
IMKIMHSLGIKLVPTHI

Download         Length: 294 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References