Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1049219..1050462 Replicon chromosome
Accession NZ_LS483471
Organism Streptococcus cristatus strain NCTC13807

Toxin (Protein)


Gene name sezT Uniprot ID A0A512A940
Locus tag DQN71_RS05385 Protein ID WP_015604931.1
Coordinates 1049695..1050462 (+) Length 256 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID A0A512A997
Locus tag DQN71_RS05380 Protein ID WP_015604930.1
Coordinates 1049219..1049695 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN71_RS05355 1044524..1044706 - 183 WP_197712457.1 DUF3173 domain-containing protein -
DQN71_RS05360 1044978..1046339 - 1362 WP_015604928.1 hypothetical protein -
DQN71_RS05370 1046756..1047766 - 1011 WP_111694538.1 site-specific integrase -
DQN71_RS05375 1048638..1049000 + 363 WP_000479225.1 hypothetical protein -
DQN71_RS05380 1049219..1049695 + 477 WP_015604930.1 helix-turn-helix domain-containing protein Antitoxin
DQN71_RS05385 1049695..1050462 + 768 WP_015604931.1 zeta toxin family protein Toxin
DQN71_RS05390 1050822..1051055 + 234 WP_006145693.1 hypothetical protein -
DQN71_RS05395 1051076..1051630 + 555 WP_015604932.1 hypothetical protein -
DQN71_RS05400 1051700..1052122 + 423 WP_015604933.1 hypothetical protein -
DQN71_RS05405 1052263..1052595 + 333 Protein_970 hypothetical protein -
DQN71_RS11660 1052605..1052925 + 321 Protein_971 hypothetical protein -
DQN71_RS11665 1052944..1053255 + 312 WP_172456458.1 hypothetical protein -
DQN71_RS05415 1053279..1053611 + 333 WP_015604936.1 hypothetical protein -
DQN71_RS05420 1053664..1054137 + 474 WP_015604937.1 SMI1/KNR4 family protein -
DQN71_RS05425 1054227..1054562 + 336 WP_015604938.1 hypothetical protein -
DQN71_RS05430 1054604..1055005 + 402 WP_015604939.1 hypothetical protein -
DQN71_RS05435 1055051..1055401 + 351 WP_015604940.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 944560..1075581 131021


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 256 a.a.        Molecular weight: 29217.98 Da        Isoelectric Point: 6.1697

>T292609 WP_015604931.1 NZ_LS483471:1049695-1050462 [Streptococcus cristatus]
MKLEEFSQDDFERASRRLVRSLTRGKTTSSHPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGQMVEYLVDELSKKGYHLLIEGTLRTTEVPRKTAQLLATRGYQVSLALIATKPELSYLSTLIRYEE
LYAIDPSQARATPKEHHDGIVEHLVDNLRELENDKIFNQIQIYQRDQSCVYDSQVDGTSAAEVLQECLFGKWSKVEEEML
NWGQERLRELGEIDK

Download         Length: 768 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18065.51 Da        Isoelectric Point: 4.4367

>AT292609 WP_015604930.1 NZ_LS483471:1049219-1049695 [Streptococcus cristatus]
MIGENIKTLRKAHNLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRFQDEQGIAFDDTSNPWVLMSDDLSDLINTRIYLVATFEDIERFNGYLDGIERMLEQASHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A512A940

Antitoxin

Source ID Structure
AlphaFold DB A0A512A997

References