Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/-
Location 1628137..1628783 Replicon chromosome
Accession NZ_LS483470
Organism Leminorella richardii strain NCTC12151

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DQM29_RS07575 Protein ID WP_111740118.1
Coordinates 1628137..1628412 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DQM29_RS07580 Protein ID WP_111742031.1
Coordinates 1628415..1628783 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM29_RS07550 1623721..1625077 + 1357 Protein_1462 MFS transporter -
DQM29_RS07555 1625080..1625876 + 797 Protein_1463 sugar phosphate isomerase/epimerase -
DQM29_RS07560 1625906..1626763 + 858 WP_111740115.1 oxidoreductase -
DQM29_RS07565 1626945..1627649 + 705 WP_111740116.1 transcriptional regulator NanR -
DQM29_RS07570 1627661..1627975 + 315 WP_111740117.1 hypothetical protein -
DQM29_RS07575 1628137..1628412 + 276 WP_111740118.1 type II toxin-antitoxin system HicA family toxin Toxin
DQM29_RS07580 1628415..1628783 + 369 WP_111742031.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQM29_RS07585 1628882..1629931 - 1050 WP_111740119.1 DUF695 domain-containing protein -
DQM29_RS07590 1630266..1630886 - 621 WP_111740120.1 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP diphosphatase HisIE -
DQM29_RS07595 1630880..1631656 - 777 WP_111740121.1 imidazole glycerol phosphate synthase subunit HisF -
DQM29_RS07600 1631638..1632375 - 738 WP_111740122.1 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino]imidazole-4- carboxamide isomerase -
DQM29_RS07605 1632382..1632969 - 588 WP_111740123.1 imidazole glycerol phosphate synthase subunit HisH -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(30-80)

Antitoxin

Uncharacterised protein family HicB

(63-115)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 9942.61 Da        Isoelectric Point: 10.1492

>T292605 WP_111740118.1 NZ_LS483470:1628137-1628412 [Leminorella richardii]
MQEKVLLLRKKQYSTLSQLFKIPALAGIKWKDIESLVIALGGEVQEGNGSRVKFFLAGSIAHFHRPHPSPDTDKGAVVSV
GDWLMSLGVTP

Download         Length: 276 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 13736.62 Da        Isoelectric Point: 5.6859

>AT292605 WP_111742031.1 NZ_LS483470:1628415-1628783 [Leminorella richardii]
MKKQPDINTLNTMVVAGQPAIISFVPELGAFRGRFLGLSGYCDFVADSISALKHEGEISLREYLEDCKEHGIEPYARKEK
QRTFTLRYPESFGEQLEHAAAASEVSLNSFIVDVLKERLSRQ

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References