Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1250684..1251286 Replicon chromosome
Accession NZ_LS483470
Organism Leminorella richardii strain NCTC12151

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag DQM29_RS05970 Protein ID WP_197708850.1
Coordinates 1250684..1250863 (+) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag DQM29_RS05975 Protein ID WP_111739802.1
Coordinates 1250876..1251286 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQM29_RS05950 1246903..1247502 + 600 WP_111739794.1 adenylyl-sulfate kinase -
DQM29_RS05955 1248092..1248865 + 774 WP_111739796.1 trans-aconitate 2-methyltransferase -
DQM29_RS05960 1248907..1249896 - 990 WP_111739798.1 sulfate ABC transporter substrate-binding protein -
DQM29_RS05965 1250096..1250500 + 405 WP_111739800.1 DUF1311 domain-containing protein -
DQM29_RS05970 1250684..1250863 + 180 WP_197708850.1 type II toxin-antitoxin system HicA family toxin Toxin
DQM29_RS05975 1250876..1251286 + 411 WP_111739802.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQM29_RS05980 1251324..1251734 + 411 WP_111739804.1 Cu(I)-responsive transcriptional regulator -
DQM29_RS05985 1252162..1253469 + 1308 WP_111739806.1 MFS transporter -
DQM29_RS05990 1253866..1255731 + 1866 WP_111742013.1 SLC13 family permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-126)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6718.98 Da        Isoelectric Point: 10.9132

>T292602 WP_197708850.1 NZ_LS483470:1250684-1250863 [Leminorella richardii]
MDSKNVIAMIEADGWYLVRIKGSHHQFKHPLKKGLVTVKHTQKDIPLPTLKSIKRQSGI

Download         Length: 180 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14892.01 Da        Isoelectric Point: 4.2860

>AT292602 WP_111739802.1 NZ_LS483470:1250876-1251286 [Leminorella richardii]
MLYPVAIDRGEESLGVRVPDIPGCFSGGDDYQDALISVKEAIEAHIELLVEDGDDVPAATNIERWLNDPEYAGAIWALVD
VDMVRLMGGAEKINVTLPKRLIAKIDRLVATRPEFKSRSGFLTQAALERISIVNNA

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References