Detailed information of TA system TA292600

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 837207..838545
• Replicon: chromosome
• Accession: NZ_LS483470
• Organism: Leminorella richardii strain NCTC12151

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: DQM29_RS03895
• Protein ID: WP_111739402.1
• Coordinates: 837207..838157 (-)
• Length: 317 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: DQM29_RS03900
• Protein ID: WP_111739403.1
• Coordinates: 838150..838545 (-)
• Length: 132 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQM29_RS03880	833230..833685	+	456	WP_111739399.1	GNAT family N-acetyltransferase	-
DQM29_RS03885	833830..835047	-	1218	WP_170126485.1	sensor histidine kinase	-
DQM29_RS03890	835239..835904	-	666	WP_111739401.1	response regulator	-
DQM29_RS03895	837207..838157	-	951	WP_111739402.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
DQM29_RS03900	838150..838545	-	396	WP_111739403.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	Antitoxin
DQM29_RS03905	838616..838848	-	233	Protein_763	DUF4942 domain-containing protein	-
DQM29_RS03915	839245..840036	-	792	WP_111739404.1	DeoR/GlpR family DNA-binding transcription regulator	-
DQM29_RS03920	840085..840981	-	897	WP_111739405.1	sugar kinase	-
DQM29_RS03925	841180..842067	+	888	WP_111739406.1	sulfolactaldehyde 3-reductase	-
DQM29_RS03930	842122..842985	+	864	WP_111739407.1	class II fructose-bisphosphate aldolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (34-303)

Antitoxin

• Protein of unknown function DUF6088 (7-108)

Sequences

Toxin

Protein

• Length: 317 a.a.
• Molecular weight: 35382.52 Da
• Isoelectric Point: 4.8402

>T292600 WP_111739402.1 NZ_LS483470:c838157-837207 [Leminorella richardii]
MDDLNVLFSDVADALGIESVAIVEKDHYIVELLRLLKQLTFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPTAAFQA
LSRNQRKNTRKAIVLAISGAITTTDVFSFDDDYPKVTRDEYCYSDIPVRYPQRVAQAPCLRPFIRLELMESNLLEPPEPR
DIHSLITALTGKAPVVSAFPCATVANTQAEKLVAMLRRTAAIVRDVERFDDASLVRHIYDTYCIVEAGGVNMPLLTDYVQ
RTIEQDIQRYGSQYPQFCTSPIDELKMGLDELACNPLYQTRYQQFVAPMVYGARKASWDEAYASFRQIALAILNAD

Nucleotide

• Length: 951 bp

Antitoxin

Protein

• Length: 132 a.a.
• Molecular weight: 14540.73 Da
• Isoelectric Point: 10.9903

>AT292600 WP_111739403.1 NZ_LS483470:c838545-838150 [Leminorella richardii]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRDLIKEGQLLKVGYGVYTKARQNSITGKVMPAAPGGSSAVIVE
TLERLKVRYRLAEETQAYNSGNSTQIPASPEIKTSSRFKRALSVGSSKLNG

Nucleotide

• Length: 396 bp