Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-ParD
Location 426364..427322 Replicon chromosome
Accession NZ_LS483468
Organism Rhodococcus coprophilus strain NCTC10994

Toxin (Protein)


Gene name pezT Uniprot ID A0A2X4U2Z6
Locus tag DQO56_RS01990 Protein ID WP_072698154.1
Coordinates 426738..427322 (+) Length 195 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A2X4TN79
Locus tag DQO56_RS01985 Protein ID WP_072698786.1
Coordinates 426364..426741 (+) Length 126 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO56_RS01955 421437..422369 - 933 WP_072698785.1 LysR family transcriptional regulator -
DQO56_RS01960 422437..423573 - 1137 WP_072698149.1 FAD-dependent oxidoreductase -
DQO56_RS01965 423602..423796 - 195 WP_072698150.1 ferredoxin -
DQO56_RS01970 423793..424971 - 1179 WP_072698151.1 cytochrome P450 -
DQO56_RS01975 425074..425451 - 378 WP_072698152.1 VOC family protein -
DQO56_RS01980 425561..426310 + 750 WP_072698153.1 TetR family transcriptional regulator -
DQO56_RS01985 426364..426741 + 378 WP_072698786.1 hypothetical protein Antitoxin
DQO56_RS01990 426738..427322 + 585 WP_072698154.1 zeta toxin family protein Toxin

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(4-136)

Antitoxin

ParD-like antitoxin of type II bacterial toxin-antitoxin system

(7-60)


Sequences

Toxin        


Download         Length: 195 a.a.        Molecular weight: 20991.78 Da        Isoelectric Point: 5.2897

>T292599 WP_072698154.1 NZ_LS483468:426738-427322 [Rhodococcus coprophilus]
VRRLDLVVGPNGSGKSTFVEQRLAPLLPGSVFVNADVIAKQRWPDSPEEHSYEAAQIAATIRDLLIDQGESFIAETVFSH
PSKLDLIDRAQRAGYVVVLHVVLVPVELSVARVAERVVEGGHRVPEEKIRSRFDRLWPLVADAIGRADHATVYDNTAADV
TRIAARFVDGDAVGEVAWPAWTPAALTGAPTVSG

Download         Length: 585 bp

Antitoxin


Download         Length: 126 a.a.        Molecular weight: 13746.32 Da        Isoelectric Point: 5.6526

>AT292599 WP_072698786.1 NZ_LS483468:426364-426741 [Rhodococcus coprophilus]
MTNVVDKVTRFSSELVDAAASEGERENRSARQQLEHWARVGREVSNQRQVARRRVEAALAGRLPLRELSDEEGVVFNAEI
AAALEESLATGHHVDDRAARGLASVVLDEQGRVVKHLPDGTQIVL

Download         Length: 378 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2X4U2Z6

Antitoxin

Source ID Structure
AlphaFold DB A0A2X4TN79

References