Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1597094..1598652 Replicon chromosome
Accession NZ_LS483458
Organism Haemophilus haemolyticus strain NCTC10839

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DQN30_RS07960 Protein ID WP_111697132.1
Coordinates 1597372..1598652 (+) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag DQN30_RS07955 Protein ID WP_111696903.1
Coordinates 1597094..1597372 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN30_RS07930 1592473..1593699 + 1227 WP_046952856.1 Ni/Fe-hydrogenase cytochrome b subunit -
DQN30_RS07935 1593699..1595408 + 1710 WP_111696900.1 hydrogenase 2 large subunit -
DQN30_RS07940 1595408..1595881 + 474 WP_111696901.1 HyaD/HybD family hydrogenase maturation endopeptidase -
DQN30_RS07945 1595973..1596482 + 510 WP_111696902.1 hydrogenase-2 assembly chaperone -
DQN30_RS07950 1596512..1596787 + 276 WP_005626486.1 hydrogenase maturation factor HybG -
DQN30_RS07955 1597094..1597372 + 279 WP_111696903.1 helix-turn-helix domain-containing protein Antitoxin
DQN30_RS07960 1597372..1598652 + 1281 WP_111697132.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN30_RS07965 1598727..1599122 - 396 WP_111696904.1 HNH endonuclease -
DQN30_RS07970 1599109..1599516 - 408 WP_111696905.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
DQN30_RS07975 1599564..1602428 - 2865 WP_111696906.1 valine--tRNA ligase -
DQN30_RS07980 1603156..1603458 - 303 Protein_1510 ASCH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-63)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49091.36 Da        Isoelectric Point: 8.0540

>T292597 WP_111697132.1 NZ_LS483458:1597372-1598652 [Haemophilus haemolyticus]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGQSRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLLVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWIIRLPQEDMCQSLNIAPARKYENDGGPSILQIMSLLNGSSNAQADRKQFFKAQIVFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLIKHNGLQKQKVKMAMAWHGENKHYLWDKIQLRHIFNTAKLTGLATETVENILHEISALYPRVSE
INTHGLPDEIVEPILMGLEMQMKKIS

Download         Length: 1281 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10430.83 Da        Isoelectric Point: 5.1651

>AT292597 WP_111696903.1 NZ_LS483458:1597094-1597372 [Haemophilus haemolyticus]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLSGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSDTARSIK
EPTATYDDDEAW

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References