Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1707739..1708407 Replicon chromosome
Accession NZ_LS483451
Organism Streptococcus pneumoniae strain 4041STDY6836166

Toxin (Protein)


Gene name hicA Uniprot ID I0T4C6
Locus tag DQL01_RS09070 Protein ID WP_001132287.1
Coordinates 1708228..1708407 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag DQL01_RS09065 Protein ID WP_000961810.1
Coordinates 1707739..1708191 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL01_RS09040 1704063..1704806 - 744 WP_061756712.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
DQL01_RS09045 1704808..1705758 - 951 WP_023396409.1 50S ribosomal protein L11 methyltransferase -
DQL01_RS09050 1705896..1706330 - 435 WP_061756711.1 NUDIX hydrolase -
DQL01_RS09055 1706380..1706922 - 543 WP_000891117.1 hypothetical protein -
DQL01_RS09060 1706978..1707448 - 471 WP_061756709.1 DUF3013 family protein -
DQL01_RS09065 1707739..1708191 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQL01_RS09070 1708228..1708407 - 180 WP_001132287.1 type II toxin-antitoxin system HicA family toxin Toxin
DQL01_RS09075 1708544..1708726 - 183 WP_111702688.1 hypothetical protein -
DQL01_RS09080 1708888..1710159 + 1272 WP_111702689.1 replication-associated recombination protein A -
DQL01_RS09090 1710704..1712023 - 1320 WP_111702690.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6697.91 Da        Isoelectric Point: 11.0174

>T292592 WP_001132287.1 NZ_LS483451:c1708407-1708228 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT292592 WP_000961810.1 NZ_LS483451:c1708191-1707739 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0T4C6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References