292590

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1169150..1169648 Replicon chromosome
Accession NZ_LS483451
Organism Streptococcus pneumoniae strain 4041STDY6836166

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag DQL01_RS06170 Protein ID WP_044788589.1
Coordinates 1169150..1169404 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag DQL01_RS06175 Protein ID WP_000208080.1
Coordinates 1169406..1169648 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL01_RS06155 1164471..1166939 - 2469 WP_001152996.1 DNA gyrase subunit A -
DQL01_RS06160 1167133..1168119 + 987 WP_000204727.1 L-lactate dehydrogenase -
DQL01_RS06165 1168391..1169103 - 713 Protein_1152 ion transporter -
DQL01_RS06170 1169150..1169404 - 255 WP_044788589.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL01_RS06175 1169406..1169648 - 243 WP_000208080.1 hypothetical protein Antitoxin
DQL01_RS06180 1169739..1170548 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
DQL01_RS06185 1170550..1171899 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
DQL01_RS06190 1171892..1172596 - 705 WP_000722076.1 response regulator transcription factor -
DQL01_RS06195 1172651..1173826 - 1176 WP_000886145.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10025.79 Da        Isoelectric Point: 11.0123

>T292590 WP_044788589.1 NZ_LS483451:c1169404-1169150 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLKAPRQHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT292590 WP_000208080.1 NZ_LS483451:c1169648-1169406 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References