Detailed information of TA system TA292589

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1012735..1013972
• Replicon: chromosome
• Accession: NZ_LS483451
• Organism: Streptococcus pneumoniae strain 4041STDY6836166

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: -
• Locus tag: DQL01_RS05450
• Protein ID: WP_111702552.1
• Coordinates: 1013211..1013972 (+)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: B6ZCC4
• Locus tag: DQL01_RS05445
• Protein ID: WP_000579612.1
• Coordinates: 1012735..1013211 (+)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL01_RS05425	1008055..1009062	+	1008	WP_001180357.1	iron ABC transporter permease	-
DQL01_RS05430	1009062..1009856	+	795	WP_000677520.1	ABC transporter ATP-binding protein	-
DQL01_RS05435	1009961..1011267	-	1307	Protein_1011	transposase	-
DQL01_RS05440	1011379..1012341	+	963	Protein_1012	IS1380-like element ISSpn5 family transposase	-
DQL01_RS05445	1012735..1013211	+	477	WP_000579612.1	helix-turn-helix domain-containing protein	Antitoxin
DQL01_RS05450	1013211..1013972	+	762	WP_111702552.1	zeta toxin family protein	Toxin
DQL01_RS05455	1014000..1014776	+	777	Protein_1015	hypothetical protein	-
DQL01_RS05460	1014704..1015156	+	453	WP_001808559.1	hypothetical protein	-
DQL01_RS05465	1016050..1016334	+	285	WP_111702553.1	hypothetical protein	-
DQL01_RS05470	1016344..1016709	+	366	WP_111702554.1	MobC family plasmid mobilization relaxosome protein	-
DQL01_RS12145	1016696..1018546	+	1851	Protein_1019	relaxase/mobilization nuclease domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29157.22 Da
• Isoelectric Point: 7.1308

>T292589 WP_111702552.1 NZ_LS483451:1013211-1013972 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSVADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18245.68 Da
• Isoelectric Point: 4.4188

>AT292589 WP_000579612.1 NZ_LS483451:1012735-1013211 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Antitoxin

• AlphaFold DB: B6ZCC4