Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1699420..1700088 Replicon chromosome
Accession NZ_LS483450
Organism Streptococcus pneumoniae strain 4041STDY6583227

Toxin (Protein)


Gene name hicA Uniprot ID I0T4C6
Locus tag DQL12_RS09095 Protein ID WP_001132287.1
Coordinates 1699909..1700088 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag DQL12_RS09090 Protein ID WP_000961810.1
Coordinates 1699420..1699872 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL12_RS09060 1694840..1695583 - 744 WP_111695778.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
DQL12_RS09065 1695585..1696535 - 951 WP_000451146.1 50S ribosomal protein L11 methyltransferase -
DQL12_RS09070 1696673..1697146 - 474 WP_000631889.1 GNAT family N-acetyltransferase -
DQL12_RS09075 1697143..1697571 - 429 WP_050217633.1 NUDIX hydrolase -
DQL12_RS09080 1697552..1698640 - 1089 WP_000719722.1 M50 family metallopeptidase -
DQL12_RS09085 1698659..1699129 - 471 WP_000257097.1 DUF3013 family protein -
DQL12_RS09090 1699420..1699872 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQL12_RS09095 1699909..1700088 - 180 WP_001132287.1 type II toxin-antitoxin system HicA family toxin Toxin
DQL12_RS09100 1700225..1700404 - 180 WP_001048906.1 hypothetical protein -
DQL12_RS09110 1700569..1700784 - 216 WP_075588414.1 hypothetical protein -
DQL12_RS09115 1701082..1702353 + 1272 WP_001113213.1 replication-associated recombination protein A -
DQL12_RS09125 1702898..1704217 - 1320 WP_000502540.1 glycoside hydrolase family 32 protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6697.91 Da        Isoelectric Point: 11.0174

>T292588 WP_001132287.1 NZ_LS483450:c1700088-1699909 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERPITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT292588 WP_000961810.1 NZ_LS483450:c1699872-1699420 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB I0T4C6

Antitoxin

Source ID Structure
PDB 5YRZ
AlphaFold DB G0IC64

References