Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1211738..1212236 Replicon chromosome
Accession NZ_LS483450
Organism Streptococcus pneumoniae strain 4041STDY6583227

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag DQL12_RS06445 Protein ID WP_001809704.1
Coordinates 1211738..1211992 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag DQL12_RS06450 Protein ID WP_000208080.1
Coordinates 1211994..1212236 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL12_RS06440 1209792..1211663 - 1872 WP_000150986.1 Eco57I restriction-modification methylase domain-containing protein -
DQL12_RS06445 1211738..1211992 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQL12_RS06450 1211994..1212236 - 243 WP_000208080.1 hypothetical protein Antitoxin
DQL12_RS06455 1212327..1213136 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
DQL12_RS06460 1213138..1214487 - 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK -
DQL12_RS06465 1214480..1215184 - 705 WP_000722076.1 response regulator transcription factor -
DQL12_RS06470 1215239..1216414 - 1176 WP_000886147.1 A/G-specific adenine glycosylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T292586 WP_001809704.1 NZ_LS483450:c1211992-1211738 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT292586 WP_000208080.1 NZ_LS483450:c1212236-1211994 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References