Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | pezAT/zeta-couple_hipB |
| Location | 1077351..1078585 | Replicon | chromosome |
| Accession | NZ_LS483450 | ||
| Organism | Streptococcus pneumoniae strain 4041STDY6583227 | ||
Toxin (Protein)
| Gene name | pezT | Uniprot ID | E6Y3Z8 |
| Locus tag | DQL12_RS05780 | Protein ID | WP_000405369.1 |
| Coordinates | 1077351..1078109 (-) | Length | 253 a.a. |
Antitoxin (Protein)
| Gene name | pezA | Uniprot ID | - |
| Locus tag | DQL12_RS05785 | Protein ID | WP_000579623.1 |
| Coordinates | 1078109..1078585 (-) | Length | 159 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| DQL12_RS05755 | 1072991..1073914 | + | 924 | WP_000417606.1 | protein rep | - |
| DQL12_RS05765 | 1074710..1075429 | - | 720 | Protein_1066 | type A chloramphenicol O-acetyltransferase | - |
| DQL12_RS05770 | 1075600..1075848 | - | 249 | WP_001814254.1 | hypothetical protein | - |
| DQL12_RS05775 | 1076087..1076875 | - | 789 | WP_000214003.1 | hypothetical protein | - |
| DQL12_RS05780 | 1077351..1078109 | - | 759 | WP_000405369.1 | zeta toxin family protein | Toxin |
| DQL12_RS05785 | 1078109..1078585 | - | 477 | WP_000579623.1 | helix-turn-helix domain-containing protein | Antitoxin |
| DQL12_RS05790 | 1078653..1078925 | - | 273 | WP_000495438.1 | hypothetical protein | - |
| DQL12_RS05795 | 1078963..1079346 | - | 384 | WP_002933294.1 | hypothetical protein | - |
| DQL12_RS05800 | 1079343..1079576 | - | 234 | WP_000152419.1 | hypothetical protein | - |
| DQL12_RS05805 | 1079627..1080712 | - | 1086 | WP_001019160.1 | toprim domain-containing protein | - |
| DQL12_RS05810 | 1080722..1081363 | - | 642 | WP_000933082.1 | hypothetical protein | - |
| DQL12_RS05815 | 1081523..1081720 | + | 198 | WP_004249782.1 | hypothetical protein | - |
| DQL12_RS05820 | 1081734..1082030 | - | 297 | WP_000998891.1 | hypothetical protein | - |
| DQL12_RS05825 | 1082044..1082328 | - | 285 | WP_000969641.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Integrative and Conjugative Element | cat(pC194) / tet(M) | - | 1020982..1110519 | 89537 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 253 a.a. Molecular weight: 28911.84 Da Isoelectric Point: 7.5459
>T292585 WP_000405369.1 NZ_LS483450:c1078109-1077351 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKYFAGKMVESLVRELSHLGYNLLIEGTLRTIDVPKKTAQLLKSRGYEIQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRGCVYDAKENTTSAADVLQELLFGEWSQVEKDML
KSGEERLKDLTN
Download Length: 759 bp
Antitoxin
Download Length: 159 a.a. Molecular weight: 18259.71 Da Isoelectric Point: 4.4258
>AT292585 WP_000579623.1 NZ_LS483450:c1078585-1078109 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA
Download Length: 477 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|