Detailed information of TA system TA292584

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-couple_hipB
• Location: 1069551..1070788
• Replicon: chromosome
• Accession: NZ_LS483450
• Organism: Streptococcus pneumoniae strain 4041STDY6583227

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: A0A4J1QI61
• Locus tag: DQL12_RS05735
• Protein ID: WP_050255691.1
• Coordinates: 1069551..1070312 (-)
• Length: 254 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: -
• Locus tag: DQL12_RS05740
• Protein ID: WP_000579613.1
• Coordinates: 1070312..1070788 (-)
• Length: 159 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
DQL12_RS05710	1064977..1066827	-	1851	WP_001865166.1	relaxase/mobilization nuclease domain-containing protein	-
DQL12_RS05715	1066814..1067179	-	366	WP_000263054.1	MobC family plasmid mobilization relaxosome protein	-
DQL12_RS05720	1067189..1067548	-	360	WP_000003750.1	hypothetical protein	-
DQL12_RS05725	1068367..1068819	-	453	WP_001808559.1	hypothetical protein	-
DQL12_RS05730	1068747..1069523	-	777	Protein_1060	hypothetical protein	-
DQL12_RS05735	1069551..1070312	-	762	WP_050255691.1	zeta toxin family protein	Toxin
DQL12_RS05740	1070312..1070788	-	477	WP_000579613.1	helix-turn-helix domain-containing protein	Antitoxin
DQL12_RS05745	1071233..1071688	-	456	WP_000500474.1	hypothetical protein	-
DQL12_RS05750	1071963..1072787	-	825	Protein_1064	alpha-glycosidase	-
DQL12_RS05755	1072991..1073914	+	924	WP_000417606.1	protein rep	-
DQL12_RS05765	1074710..1075429	-	720	Protein_1066	type A chloramphenicol O-acetyltransferase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Integrative and Conjugative Element	cat(pC194) / tet(M)	-	1020982..1110519	89537

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (25-215)

Antitoxin

• Cro/C1-type helix-turn-helix domain (3-60)

Sequences

Toxin

Protein

• Length: 254 a.a.
• Molecular weight: 29157.22 Da
• Isoelectric Point: 7.1308

>T292584 WP_050255691.1 NZ_LS483450:c1070312-1069551 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLRYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLVLIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Nucleotide

• Length: 762 bp

Antitoxin

Protein

• Length: 159 a.a.
• Molecular weight: 18249.67 Da
• Isoelectric Point: 4.3462

>AT292584 WP_000579613.1 NZ_LS483450:c1070788-1070312 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Nucleotide

• Length: 477 bp

Structures

Toxin

• AlphaFold DB: A0A4J1QI61