Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 952703..953949 Replicon chromosome
Accession NZ_LS483450
Organism Streptococcus pneumoniae strain 4041STDY6583227

Toxin (Protein)


Gene name zeta Uniprot ID -
Locus tag DQL12_RS05145 Protein ID WP_000405354.1
Coordinates 952703..953473 (-) Length 257 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID -
Locus tag DQL12_RS05150 Protein ID WP_000579623.1
Coordinates 953473..953949 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL12_RS05115 948683..949048 - 366 WP_000401236.1 plasmid mobilization relaxosome protein MobC -
DQL12_RS05120 949053..949409 - 357 WP_000827835.1 hypothetical protein -
DQL12_RS05125 949704..949994 - 291 WP_001080184.1 hypothetical protein -
DQL12_RS05130 949984..950349 - 366 WP_000981955.1 hypothetical protein -
DQL12_RS05135 950346..951761 - 1416 WP_000118333.1 Y-family DNA polymerase -
DQL12_RS05140 951764..952447 - 684 WP_050255678.1 LexA family transcriptional regulator -
DQL12_RS05145 952703..953473 - 771 WP_000405354.1 zeta toxin family protein Toxin
DQL12_RS05150 953473..953949 - 477 WP_000579623.1 helix-turn-helix domain-containing protein Antitoxin
DQL12_RS05155 954225..954680 - 456 WP_025173400.1 hypothetical protein -
DQL12_RS05160 954948..956693 - 1746 Protein_951 alpha-glycosidase -
DQL12_RS05165 956856..957740 - 885 WP_000710115.1 diacylglycerol kinase family lipid kinase -
DQL12_RS05170 957852..958706 - 855 WP_050079171.1 ADP-ribosylglycohydrolase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-214)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 257 a.a.        Molecular weight: 29234.14 Da        Isoelectric Point: 7.5403

>T292583 WP_000405354.1 NZ_LS483450:c953473-952703 [Streptococcus pneumoniae]
VEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTVDVPKKTAQLLKNKGYEVQLALIATKPKLSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVNNTRQLEELAIFERIQIYQRDRSCVYDSGEDKTSAATVLHDLLFGEWNQVEKEML
KSGEERLKDLTNRNGC

Download         Length: 771 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18259.71 Da        Isoelectric Point: 4.4258

>AT292583 WP_000579623.1 NZ_LS483450:c953949-953473 [Streptococcus pneumoniae]
MIGKNIKSLRKTHELTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References