292582

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1645681..1646349 Replicon chromosome
Accession NZ_LS483449
Organism Streptococcus pneumoniae strain 4041STDY6836170

Toxin (Protein)


Gene name hicA Uniprot ID C1C927
Locus tag DQK98_RS08595 Protein ID WP_001132282.1
Coordinates 1646170..1646349 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID G0IC64
Locus tag DQK98_RS08590 Protein ID WP_000961810.1
Coordinates 1645681..1646133 (-) Length 151 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQK98_RS08560 1641101..1641844 - 744 WP_001188200.1 16S rRNA (uracil(1498)-N(3))-methyltransferase -
DQK98_RS08565 1641846..1642796 - 951 WP_024477875.1 50S ribosomal protein L11 methyltransferase -
DQK98_RS08570 1642934..1643407 - 474 WP_000631889.1 GNAT family N-acetyltransferase -
DQK98_RS08575 1643404..1643832 - 429 WP_111688155.1 NUDIX hydrolase -
DQK98_RS08580 1643813..1644901 - 1089 WP_050308821.1 M50 family metallopeptidase -
DQK98_RS08585 1644920..1645390 - 471 WP_000257097.1 DUF3013 family protein -
DQK98_RS08590 1645681..1646133 - 453 WP_000961810.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQK98_RS08595 1646170..1646349 - 180 WP_001132282.1 type II toxin-antitoxin system HicA family toxin Toxin
DQK98_RS08600 1646486..1646665 - 180 WP_001048906.1 hypothetical protein -
DQK98_RS08610 1646830..1647045 - 216 WP_075329187.1 hypothetical protein -
DQK98_RS08615 1647333..1648604 + 1272 WP_001113225.1 replication-associated recombination protein A -
DQK98_RS08625 1649024..1649737 - 714 WP_172448788.1 site-specific integrase -
DQK98_RS08630 1649887..1650150 - 264 WP_050073086.1 Arm DNA-binding domain-containing protein -
DQK98_RS08635 1650152..1650334 - 183 WP_000655516.1 DUF3173 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(6-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(17-114)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6713.95 Da        Isoelectric Point: 11.0174

>T292582 WP_001132282.1 NZ_LS483449:c1646349-1646170 [Streptococcus pneumoniae]
MPMTQKEMVKLLTAHGWIKTRGGKGSHIKMEKQGERLITIPHGELNKYTERGIRKQAGL

Download         Length: 180 bp

Antitoxin


Download         Length: 151 a.a.        Molecular weight: 16659.46 Da        Isoelectric Point: 3.7220

>AT292582 WP_000961810.1 NZ_LS483449:c1646133-1645681 [Streptococcus pneumoniae]
MLVTYPALFYYDDTDGTEATYFVHFPDFEYSATQGEGISEALAMGSEWLGITVADLIESDGELPQPSDINSLSLIDNDPF
KDDEDFVSTYDLDKSFISMVSVDVSEYLGSQEPIKKTLTIPKWADKLGREMGLNFSQTLTDAIADKKVQA

Download         Length: 453 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E7SUI3

Antitoxin

Source ID Structure
AlphaFold DB G0IC64

References