Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 5079562..5080229 Replicon chromosome
Accession NC_020800
Organism Xanthomonas axonopodis Xac29-1

Toxin (Protein)


Gene name vapC Uniprot ID M4U0C6
Locus tag XAC29_RS44525 Protein ID WP_005916679.1
Coordinates 5079813..5080229 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID M4U000
Locus tag XAC29_RS44520 Protein ID WP_005916676.1
Coordinates 5079562..5079816 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
XAC29_RS44495 5075684..5075903 + 220 Protein_4264 RNA 2'-phosphotransferase -
XAC29_RS44500 5076060..5077325 + 1266 WP_015463799.1 cardiolipin synthase B -
XAC29_RS44505 5077351..5077878 - 528 WP_005916668.1 hypothetical protein -
XAC29_RS44510 5078117..5078323 + 207 WP_003489327.1 hypothetical protein -
XAC29_RS44515 5078310..5079416 + 1107 WP_005916674.1 type II toxin-antitoxin system RelE/ParE family toxin -
XAC29_RS44520 5079562..5079816 + 255 WP_005916676.1 Arc family DNA-binding protein Antitoxin
XAC29_RS44525 5079813..5080229 + 417 WP_005916679.1 type II toxin-antitoxin system VapC family toxin Toxin
XAC29_RS48215 5080351..5080554 - 204 WP_131830033.1 hypothetical protein -
XAC29_RS48220 5080682..5080894 - 213 WP_015472901.1 hypothetical protein -
XAC29_RS44530 5081151..5082770 + 1620 WP_015463800.1 hypothetical protein -
XAC29_RS44535 5082874..5083272 - 399 WP_004429277.1 DUF2384 domain-containing protein -
XAC29_RS44540 5083588..5084019 + 432 WP_005922907.1 hypothetical protein -
XAC29_RS47560 5084048..5084374 - 327 Protein_4276 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-127)

Antitoxin

Arc-like DNA binding domain

(1-39)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 14795.09 Da        Isoelectric Point: 5.6920

>T29258 WP_005916679.1 NC_020800:5079813-5080229 [Xanthomonas axonopodis Xac29-1]
VILLDTNVISELWRPQPNPQVVAWIDAQAVETLFLSVVTVAELRFGIAVMPKGRKRSTLHARLEGEVLPLFDGRLLAFDL
DASHAFAALASKARTAGLTLGRADAYIAATAAAQGLTVATRDTAPFEAMALDVINPWS

Download         Length: 417 bp

>T29258 NC_020800:5079813-5080229 [Xanthomonas axonopodis Xac29-1]
GTGATCCTGCTCGATACCAATGTCATCTCCGAACTTTGGCGGCCTCAGCCTAATCCGCAGGTCGTCGCCTGGATCGATGC
ACAAGCTGTCGAGACACTGTTCCTGTCGGTCGTGACGGTGGCTGAACTCCGTTTCGGTATTGCCGTGATGCCCAAGGGCC
GAAAGCGATCCACCTTGCATGCTCGGTTGGAGGGCGAGGTATTGCCACTGTTCGACGGGCGCCTGCTCGCATTCGATCTG
GATGCATCACACGCATTTGCGGCGCTTGCATCGAAAGCCAGAACCGCAGGACTCACACTCGGGCGCGCCGATGCCTACAT
CGCTGCAACAGCAGCCGCGCAAGGATTGACCGTTGCCACTCGCGACACGGCACCATTCGAGGCGATGGCGTTAGACGTCA
TTAACCCTTGGAGTTGA

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 8996.53 Da        Isoelectric Point: 11.3362

>AT29258 WP_005916676.1 NC_020800:5079562-5079816 [Xanthomonas axonopodis Xac29-1]
MPSFTVRNIPDDVHRAIRARAALHGRSTEAEIRAILELAAKPADRVKLGSLLVSIGRDAGLTAKEANAFDKLRGKAAIKP
IGLK

Download         Length: 255 bp

>AT29258 NC_020800:5079562-5079816 [Xanthomonas axonopodis Xac29-1]
ATGCCTTCTTTCACCGTCCGCAATATCCCAGACGACGTGCATCGCGCGATCCGCGCGCGGGCTGCACTTCATGGCCGCAG
CACCGAAGCGGAGATCCGCGCAATCCTTGAATTGGCGGCCAAACCCGCAGACCGGGTCAAACTCGGCTCACTGCTGGTGA
GCATCGGCCGCGACGCCGGCCTGACCGCAAAAGAGGCCAATGCCTTCGACAAGCTGCGCGGCAAGGCGGCGATCAAGCCG
ATCGGTCTGAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB M4U0C6

Antitoxin

Source ID Structure
AlphaFold DB A0A828YKJ0

References