292577

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 1146124..1146622 Replicon chromosome
Accession NZ_LS483448
Organism Streptococcus pneumoniae strain 4041STDY6836167

Toxin (Protein)


Gene name relE Uniprot ID B1IC19
Locus tag DQK99_RS06095 Protein ID WP_001809704.1
Coordinates 1146124..1146378 (-) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID B1IC20
Locus tag DQK99_RS06100 Protein ID WP_000208080.1
Coordinates 1146380..1146622 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQK99_RS06080 1141407..1143875 - 2469 WP_001152990.1 DNA gyrase subunit A -
DQK99_RS06085 1144069..1145055 + 987 WP_000204727.1 L-lactate dehydrogenase -
DQK99_RS06090 1145404..1146077 - 674 Protein_1146 ion transporter -
DQK99_RS06095 1146124..1146378 - 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQK99_RS06100 1146380..1146622 - 243 WP_000208080.1 hypothetical protein Antitoxin
DQK99_RS06105 1146699..1147513 - 815 Protein_1149 IS5-like element IS1515 family transposase -
DQK99_RS06115 1147689..1148945 + 1257 WP_000530078.1 ISL3 family transposase -
DQK99_RS06120 1149009..1149818 - 810 WP_001289493.1 MBL fold metallo-hydrolase -
DQK99_RS06125 1149820..1151169 - 1350 WP_000886213.1 cell wall metabolism sensor histidine kinase VicK -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-84)

Antitoxin

Protein of unknown function DUF6290

(1-73)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10098.79 Da        Isoelectric Point: 10.7632

>T292577 WP_001809704.1 NZ_LS483448:c1146378-1146124 [Streptococcus pneumoniae]
MYKLVPTRRFIKQLKKLDRYTQKLITNYLQTNVLEDPRRHGKALVGNRVGQWRYRIGNYRVIVQIVDDELVVATLEVGHR
RDIY

Download         Length: 255 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9205.46 Da        Isoelectric Point: 4.0527

>AT292577 WP_000208080.1 NZ_LS483448:c1146622-1146380 [Streptococcus pneumoniae]
MTTITLKVSEADKTFMKAMAKFEGVSLSELIRTKTLEALEDEYDARVADLAYQEYLEDLEKGVEPITWEEMMHDLGLKDE

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A853PEW4

Antitoxin

Source ID Structure
AlphaFold DB A0A064C2J7

References