Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) zeta-pezA/zeta-couple_hipB
Location 984908..986142 Replicon chromosome
Accession NZ_LS483448
Organism Streptococcus pneumoniae strain 4041STDY6836167

Toxin (Protein)


Gene name zeta Uniprot ID A0A0T8STN7
Locus tag DQK99_RS05365 Protein ID WP_000405351.1
Coordinates 985384..986142 (+) Length 253 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID A0A0T7YHJ0
Locus tag DQK99_RS05360 Protein ID WP_000579620.1
Coordinates 984908..985384 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQK99_RS05335 979981..980835 + 855 WP_000901913.1 ADP-ribosylglycohydrolase family protein -
DQK99_RS05340 980947..981831 + 885 WP_000757475.1 diacylglycerol kinase family lipid kinase -
DQK99_RS11830 981994..982071 + 78 WP_001810169.1 alpha amylase N-terminal ig-like domain-containing protein -
DQK99_RS05350 982135..983733 + 1599 Protein_1003 alpha amylase N-terminal ig-like domain-containing protein -
DQK99_RS05355 984008..984463 + 456 WP_000500478.1 hypothetical protein -
DQK99_RS05360 984908..985384 + 477 WP_000579620.1 helix-turn-helix domain-containing protein Antitoxin
DQK99_RS05365 985384..986142 + 759 WP_000405351.1 zeta toxin family protein Toxin
DQK99_RS05370 986540..987436 - 897 WP_000384879.1 tyrosine-type recombinase/integrase -
DQK99_RS05375 987766..989535 + 1770 WP_000002882.1 DUF4365 domain-containing protein -
DQK99_RS05380 989564..989848 + 285 WP_000403447.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 983233..1050116 66883


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 253 a.a.        Molecular weight: 28752.57 Da        Isoelectric Point: 6.5919

>T292576 WP_000405351.1 NZ_LS483448:985384-986142 [Streptococcus pneumoniae]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTELSHLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYAINPNQARATPKEHHDFIVNHLVDNTRQLEELAIFESIQIYQRDRSCVYDSKENTTSAATVLHDLLFGELNQVEKEML
KSGEERLKDLTN

Download         Length: 759 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18235.65 Da        Isoelectric Point: 4.3462

>AT292576 WP_000579620.1 NZ_LS483448:984908-985384 [Streptococcus pneumoniae]
MIGKNIKSLRKTHDLTQPEFARIVGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIQTNIYLVENFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0T8STN7

Antitoxin

Source ID Structure
AlphaFold DB A0A0T7YHJ0

References