Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 1791816..1793077 Replicon chromosome
Accession NZ_LS483444
Organism Streptococcus australis strain NCTC13166

Toxin (Protein)


Gene name sezT Uniprot ID E7S9E2
Locus tag DQL20_RS09220 Protein ID WP_006595607.1
Coordinates 1791816..1792601 (-) Length 262 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag DQL20_RS09225 Protein ID WP_006595606.1
Coordinates 1792601..1793077 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQL20_RS09205 1787279..1787836 - 558 Protein_1703 hypothetical protein -
DQL20_RS09210 1787883..1789805 - 1923 WP_006595609.1 ATP-dependent helicase -
DQL20_RS09215 1789787..1791826 - 2040 WP_006595608.1 ATP-dependent endonuclease -
DQL20_RS09220 1791816..1792601 - 786 WP_006595607.1 zeta toxin family protein Toxin
DQL20_RS09225 1792601..1793077 - 477 WP_006595606.1 helix-turn-helix domain-containing protein Antitoxin
DQL20_RS09230 1793206..1794816 - 1611 WP_006595605.1 ABC transporter ATP-binding protein/permease -
DQL20_RS09235 1795213..1796079 - 867 WP_006595604.1 helix-turn-helix transcriptional regulator -
DQL20_RS09240 1796475..1796867 - 393 WP_000075973.1 30S ribosomal protein S9 -
DQL20_RS09245 1796886..1797332 - 447 WP_002876943.1 50S ribosomal protein L13 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(26-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 262 a.a.        Molecular weight: 30036.14 Da        Isoelectric Point: 6.3961

>T292575 WP_006595607.1 NZ_LS483444:c1792601-1791816 [Streptococcus australis]
MKLEEFSQDDFGRASRRLVRSLTRGKTTSSRPKAILLGGQSGAGKTTIHRIKQREFQGNIIIIDGDSYRSFHPNYLGLQE
KYGKDSVDYTKVFAGRMVEYLVDELSKLGYHLLIEGTLRTTEVPRKTAQLLVIRGYQVSLALIATKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDEIVEHLVDNLRELENDNIFNQIQIFQRDQSCVYDSQVDETSAAEVLHECLFGKWSKVEEEMF
KMGQERLRELMEMKKGIIDGN

Download         Length: 786 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18042.50 Da        Isoelectric Point: 4.3266

>AT292575 WP_006595606.1 NZ_LS483444:c1793077-1792601 [Streptococcus australis]
MIGENIKALRKTHDLTQPEFAKIVGISRNSLSRYENGTSSVSTELIDRICQKFNVSYIDIVGEEKMLTPVEDYQLTLKIE
VIKERGANILAQLYRLQDELEIAFDDANNPWVLISDDLSDLINTKIYLVATFEDVERYNGYLDGIERMLEQASHLVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E7S9E2

Antitoxin

Source ID Structure

References