292573

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1838720..1840278 Replicon chromosome
Accession NZ_LS483443
Organism Aggregatibacter segnis ATCC 33393 strain NCTC 10977

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag DQN58_RS08960 Protein ID WP_081456144.1
Coordinates 1838998..1840278 (+) Length 427 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID E6KYQ8
Locus tag DQN58_RS08955 Protein ID WP_006718865.1
Coordinates 1838720..1838998 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN58_RS08935 1833899..1834381 - 483 WP_006718857.1 DNA starvation/stationary phase protection protein -
DQN58_RS08940 1834572..1835732 + 1161 WP_006718859.1 EmrA/EmrK family multidrug efflux transporter periplasmic adaptor subunit -
DQN58_RS08945 1835745..1837259 + 1515 WP_006718861.1 DHA2 family efflux MFS transporter permease subunit -
DQN58_RS08950 1837512..1838567 + 1056 WP_006718863.1 ABC transporter substrate-binding protein -
DQN58_RS08955 1838720..1838998 + 279 WP_006718865.1 helix-turn-helix domain-containing protein Antitoxin
DQN58_RS08960 1838998..1840278 + 1281 WP_081456144.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN58_RS08965 1840357..1840752 - 396 WP_006718869.1 HNH endonuclease -
DQN58_RS08970 1840739..1841146 - 408 WP_006718872.1 (deoxy)nucleoside triphosphate pyrophosphohydrolase -
DQN58_RS08975 1841194..1844121 - 2928 WP_006718874.1 valine--tRNA ligase -
DQN58_RS08980 1844178..1845095 - 918 WP_006718876.1 restriction endonuclease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1829688..1845095 15407


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(6-105)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-64)


Sequences

Toxin        


Download         Length: 427 a.a.        Molecular weight: 49143.45 Da        Isoelectric Point: 8.5442

>T292573 WP_081456144.1 NZ_LS483443:1838998-1840278 [Aggregatibacter segnis ATCC 33393]
MSNSILNVAMNGLLVGEWRKLTSGATEFQYAEKWLESVRSRPISLSLPLSHKIYRGDSVYNFFDNLLPDNEQIRSRIQQR
FQTSTKSPFDLLSAIGQDCIGAIQLYQGENRSVRQIYAEPLNDKEVENVLKNYRTFPLGMEESEDFRISLAGAQEKTALL
YYQNQWQRPLHSTATSHIFKLPIGMVAQGQLDLSGSCENEWLCLNIMKAFGLPVPRSQIQYFGEMKVLIVERFDRRWSEN
RSWLIRLPQEDMCQALNIAPARKYENDGGPSILQIMSLLKGSSNAQADRKQFFKAQIIFWLLCAIDGHGKNFSLFLEQEN
RYRLTPFYDVMSAYPLINHNGLQKQKVKMAMAWHGKNKHYLWDKIQPRHIFNTAKLAGLSKETVEDVLHEISALYRRVSE
INTHGLPDEIVEPILMGLEMQMKKIS

Download         Length: 1281 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10370.82 Da        Isoelectric Point: 5.1425

>AT292573 WP_006718865.1 NZ_LS483443:1838720-1838998 [Aggregatibacter segnis ATCC 33393]
MVITTAKMLSHVIREFRYQGDLSQTDVAKLAGTTQARISAFENEPERTKLETLFKILAGLELELIVQPRKKSSNTALSIK
EPTATYDDDEAW

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB E6KYQ8

References