Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 704890..705527 Replicon chromosome
Accession NZ_LS483438
Organism Haemophilus influenzae strain NCTC12975

Toxin (Protein)


Gene name VapC1 Uniprot ID E4QWH2
Locus tag DQN45_RS03565 Protein ID WP_005649049.1
Coordinates 704890..705294 (-) Length 135 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID E4QWH3
Locus tag DQN45_RS03570 Protein ID WP_005649046.1
Coordinates 705291..705527 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN45_RS03535 700448..701014 + 567 WP_005662944.1 elongation factor P -
DQN45_RS03545 701366..701953 - 588 WP_005654063.1 primosomal replication protein -
DQN45_RS03550 701986..703338 - 1353 WP_005688977.1 Na+/H+ antiporter family protein -
DQN45_RS03555 703653..704342 - 690 WP_005688979.1 ribonuclease T -
DQN45_RS03560 704416..704823 - 408 WP_005688980.1 lactoylglutathione lyase -
DQN45_RS03565 704890..705294 - 405 WP_005649049.1 type II toxin-antitoxin system VapC family toxin Toxin
DQN45_RS03570 705291..705527 - 237 WP_005649046.1 antitoxin Antitoxin
DQN45_RS03575 705620..706345 - 726 WP_005688983.1 carboxy-S-adenosyl-L-methionine synthase CmoA -
DQN45_RS03580 706398..706916 - 519 WP_005688985.1 isoprenylcysteine carboxyl methyltransferase family protein -
DQN45_RS03585 707136..708902 + 1767 WP_005688987.1 aspartate--tRNA ligase -
DQN45_RS03590 708964..709836 + 873 WP_005688989.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-124)

Antitoxin

SpoVT-AbrB domain

(6-44)


Sequences

Toxin        


Download         Length: 135 a.a.        Molecular weight: 15692.29 Da        Isoelectric Point: 8.9777

>T292569 WP_005649049.1 NZ_LS483438:c705294-704890 [Haemophilus influenzae]
MIYMLDTNIIIYLMKNRPKIIAERVSQLLPNDRLVMSFITYAELIKGAFGSQNYEQSIRAIELLTERVNVLYPNEQICLH
YGKWANTLKKQGRPIGNNDLWIACHALSLNAVLITHNVKEFQRITDLQWQDWTK

Download         Length: 405 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 9037.19 Da        Isoelectric Point: 4.2342

>AT292569 WP_005649046.1 NZ_LS483438:c705527-705291 [Haemophilus influenzae]
MLTKVFQSGNSQAVRIPMDFRFDVDTVEIFRKENGDVVLRPVSKKTDDFLALFEGFDETFIQALEARDDLPPQERENL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB E4QWH2

Antitoxin

Source ID Structure
AlphaFold DB E4QWH3

References