Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 387775..388246 Replicon chromosome
Accession NZ_LS483438
Organism Haemophilus influenzae strain NCTC12975

Toxin (Protein)


Gene name toxT Uniprot ID A0A806DTA9
Locus tag DQN45_RS01910 Protein ID WP_005654546.1
Coordinates 387775..387957 (+) Length 61 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQN45_RS01915 Protein ID WP_005650837.1
Coordinates 387950..388246 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN45_RS01905 384482..387504 + 3023 Protein_356 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQN45_RS01910 387775..387957 + 183 WP_005654546.1 shikimate 5-dehydrogenase Toxin
DQN45_RS01915 387950..388246 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQN45_RS01920 388430..390346 + 1917 WP_042594001.1 ABC transporter ATP-binding protein -
DQN45_RS01925 390356..390892 + 537 WP_042594000.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQN45_RS01930 390908..391459 + 552 WP_042593999.1 Sua5/YciO/YrdC/YwlC family protein -
DQN45_RS01935 391463..392281 + 819 WP_042593998.1 shikimate dehydrogenase -
DQN45_RS01940 392278..392835 + 558 WP_042593997.1 DNA-3-methyladenine glycosylase I -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 7318.33 Da        Isoelectric Point: 6.3057

>T292568 WP_005654546.1 NZ_LS483438:387775-387957 [Haemophilus influenzae]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVIQTAQQRLSELKERLKNE

Download         Length: 183 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292568 WP_005650837.1 NZ_LS483438:387950-388246 [Haemophilus influenzae]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A806DTA9

Antitoxin

Source ID Structure

References