Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 5752056..5753764 Replicon chromosome
Accession NZ_LS483433
Organism Pseudomonas mucidolens strain NCTC8068

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag DQO04_RS26880 Protein ID WP_084378286.1
Coordinates 5752056..5752934 (+) Length 293 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID -
Locus tag DQO04_RS26885 Protein ID WP_084378287.1
Coordinates 5752931..5753764 (+) Length 278 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO04_RS26855 5748048..5748899 + 852 WP_084378282.1 ABC transporter ATP-binding protein -
DQO04_RS26860 5748937..5749929 + 993 WP_084378283.1 ABC transporter substrate-binding protein -
DQO04_RS26865 5749958..5750734 + 777 WP_084378284.1 ABC transporter permease -
DQO04_RS26870 5750734..5751498 + 765 WP_090221644.1 SDR family oxidoreductase -
DQO04_RS26875 5751512..5752051 + 540 WP_029289969.1 cupin domain-containing protein -
DQO04_RS26880 5752056..5752934 + 879 WP_084378286.1 alpha/beta hydrolase Toxin
DQO04_RS26885 5752931..5753764 + 834 WP_084378287.1 IclR family transcriptional regulator Antitoxin
DQO04_RS26890 5753766..5754563 + 798 WP_084378288.1 SDR family oxidoreductase -
DQO04_RS26895 5754556..5756238 + 1683 WP_084378289.1 thiamine pyrophosphate-binding protein -
DQO04_RS26900 5756249..5757052 + 804 WP_084378290.1 aspartate dehydrogenase -
DQO04_RS26905 5757063..5758559 + 1497 WP_084378291.1 aldehyde dehydrogenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - algR / algC / tagR / ppkA / pppA / icmF1/tssM1 / dotU1 / hsiJ1 / hsiB1/vipA / hsiC1/vipB / hcp1 / hsiF1 / hsiG1 / hsiH1 / clpV1 / vgrG1a 5610810..5836543 225733


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(45-276)

Antitoxin

Transcription regulator IclR, N-terminal

(19-68)


Sequences

Toxin        


Download         Length: 293 a.a.        Molecular weight: 31027.51 Da        Isoelectric Point: 7.9414

>T292564 WP_084378286.1 NZ_LS483433:5752056-5752934 [Pseudomonas mucidolens]
MLPGLSQAPPTADLQAQLERDFPQRLVLAAGGRQALRECGAGPTVVMLHGIGSGAASWLQVAQHLAPRARVIAWDAPGYG
DSSPLESDAPKAEQYATRLAQMLDALSVEQCVLVGHSLGALTALALARSSQANRVSRLILISPARGYGAPQHAAQRQQVR
QQRLDNLQRLGIAGLAKERSAHMLSPCATPQALAWVRWNMERLNPVGYRQAIELLCGDDLLRHGQPDMPCEVHCGEADSI
TTAQTCLSVAKALGAGFNLIADAGHASPIEQPQVVAGRLAFAIQQSLTGTRL

Download         Length: 879 bp

Antitoxin


Download         Length: 278 a.a.        Molecular weight: 30663.15 Da        Isoelectric Point: 6.6448

>AT292564 WP_084378287.1 NZ_LS483433:5752931-5753764 [Pseudomonas mucidolens]
MNDSDLLKDAQDKYIVPGLERGLLLLCEFSRRNRTLTAPELARRLALPRSTIFRLLTTLETMGFVTRSGNEYRLGMSVLR
LGFEYLASLELTELGQPLLARLCDRLNYPSNLVVRDGRSIVYVAKVSPPSVFSNAVNVGTRLPAHATVLGRILLEDLSLA
ELRELYPEEHLEQHSPCTPKTVLELFDLVQADRQRGFISGEGFFESAISTVAAPVRDQSGSIVAALGVTIATTQIGHVNF
EELLTQVRRSADELSRLLNYNGGAHSGQPRVTALMRD

Download         Length: 834 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References