Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1600264..1600876 Replicon chromosome
Accession NZ_LS483432
Organism Streptococcus pyogenes strain NCTC13745

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag DQN32_RS08310 Protein ID WP_002994716.1
Coordinates 1600541..1600876 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag DQN32_RS08305 Protein ID WP_002988079.1
Coordinates 1600264..1600551 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN32_RS08280 1595454..1596437 - 984 WP_031488719.1 tagatose-bisphosphate aldolase -
DQN32_RS08285 1596441..1597370 - 930 WP_031488720.1 tagatose-6-phosphate kinase -
DQN32_RS08290 1597418..1597933 - 516 WP_002991700.1 galactose-6-phosphate isomerase subunit LacB -
DQN32_RS08295 1597968..1598396 - 429 WP_014635709.1 galactose-6-phosphate isomerase subunit LacA -
DQN32_RS08300 1598841..1599614 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
DQN32_RS08305 1600264..1600551 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
DQN32_RS08310 1600541..1600876 + 336 WP_002994716.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN32_RS09525 1601028..1601498 + 471 WP_021733374.1 site-specific integrase -
DQN32_RS09530 1601461..1602009 + 549 WP_180372715.1 site-specific integrase -
DQN32_RS08325 1602141..1602533 - 393 WP_002982716.1 30S ribosomal protein S9 -
DQN32_RS08330 1602554..1603000 - 447 WP_002982710.1 50S ribosomal protein L13 -
DQN32_RS08335 1603218..1603424 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
DQN32_RS08340 1603421..1603927 - 507 WP_002988070.1 hypothetical protein -
DQN32_RS08345 1604063..1604923 - 861 WP_011529009.1 DegV family protein -
DQN32_RS08350 1605020..1605538 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(7-104)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13154.89 Da        Isoelectric Point: 5.6157

>T292563 WP_002994716.1 NZ_LS483432:1600541-1600876 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQHKMEQIISDIEKLEVFPEVGFDADEKYGSKISHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTRSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT292563 WP_002988079.1 NZ_LS483432:1600264-1600551 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References