Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-MazE
Location 1458432..1459085 Replicon chromosome
Accession NZ_LS483429
Organism Haemophilus aegyptius strain NCTC8502

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag DQN49_RS07710 Protein ID WP_006996056.1
Coordinates 1458693..1459085 (+) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A5C2R5S0
Locus tag DQN49_RS07705 Protein ID WP_006996057.1
Coordinates 1458432..1458692 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN49_RS07690 1454283..1455248 - 966 WP_006996060.1 tRNA 5-methoxyuridine(34)/uridine 5-oxyacetic acid(34) synthase CmoB -
DQN49_RS07695 1455245..1456759 - 1515 WP_006996059.1 sodium/proline symporter PutP -
DQN49_RS07700 1456874..1458349 + 1476 WP_006996058.1 ribonuclease G -
DQN49_RS07705 1458432..1458692 + 261 WP_006996057.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DQN49_RS07710 1458693..1459085 + 393 WP_006996056.1 type II toxin-antitoxin system VapC family toxin Toxin
DQN49_RS07715 1459437..1460959 + 1523 Protein_1469 YadA-like family protein -
DQN49_RS07720 1461125..1462792 + 1668 WP_006996054.1 glutamine--tRNA ligase -
DQN49_RS07725 1462871..1463302 + 432 WP_167395599.1 YcgN family cysteine cluster protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-117)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14758.20 Da        Isoelectric Point: 4.6908

>T292559 WP_006996056.1 NZ_LS483429:1458693-1459085 [Haemophilus aegyptius]
MYMLDTNTVSYFFRKVPSVVERLRLLNPEILCISSVTAAELFYGVAKRNNLQLSQFLDIFLSAISILEWDTKTAEIYGKL
RAEMEKEGKVMGVQDQMIAAHALANECVLVTSDKAFEFVPNLILENWCSV

Download         Length: 393 bp

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 10301.56 Da        Isoelectric Point: 4.9010

>AT292559 WP_006996057.1 NZ_LS483429:1458432-1458692 [Haemophilus aegyptius]
MEKIARLFRNGRNQAVRLPVEFEFDATQIYVFKEENGDIRLSTRSRSQQNWQKVFELLPTIQCDEDFLSEKERKQEVATR
DPFEGF

Download         Length: 261 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A5C2R5S0

References