Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) toxTA/Tad-couple_hipB
Location 401045..401693 Replicon chromosome
Accession NZ_LS483429
Organism Haemophilus aegyptius strain NCTC8502

Toxin (Protein)


Gene name toxT Uniprot ID A0A0Y7JUP0
Locus tag DQN49_RS02150 Protein ID WP_005694481.1
Coordinates 401045..401404 (+) Length 120 a.a.

Antitoxin (Protein)


Gene name toxA Uniprot ID -
Locus tag DQN49_RS02155 Protein ID WP_005650837.1
Coordinates 401397..401693 (+) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN49_RS02145 397696..400784 + 3089 Protein_409 TonB-dependent hemoglobin/transferrin/lactoferrin family receptor -
DQN49_RS02150 401045..401404 + 360 WP_005694481.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN49_RS02155 401397..401693 + 297 WP_005650837.1 helix-turn-helix transcriptional regulator Antitoxin
DQN49_RS02160 401854..403770 + 1917 WP_006995317.1 ABC transporter ATP-binding protein -
DQN49_RS02165 403780..404316 + 537 WP_006995316.1 topoisomerase DNA-binding C4 zinc finger domain-containing protein -
DQN49_RS02170 404332..404883 + 552 WP_006995315.1 Sua5/YciO/YrdC/YwlC family protein -
DQN49_RS02175 404887..405693 + 807 WP_006995314.1 shikimate dehydrogenase -
DQN49_RS02180 405705..406457 + 753 WP_006995313.1 DUF3800 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-like

(36-109)

Antitoxin

Cro/C1-type helix-turn-helix domain

(34-89)


Sequences

Toxin        


Download         Length: 120 a.a.        Molecular weight: 14321.67 Da        Isoelectric Point: 10.1408

>T292557 WP_005694481.1 NZ_LS483429:401045-401404 [Haemophilus aegyptius]
MYEILFYRDQNDIEPVKEYLLSLAQNESKDSRIKLNKIRDYVKLLSELGTSVGKPYVKHLDGEIWELRPIRDRILFARLM
DGRFVLLHQFMKKTQKTPKREIQTAQQRLSELKERLKNE

Download         Length: 360 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11092.94 Da        Isoelectric Point: 10.3139

>AT292557 WP_005650837.1 NZ_LS483429:401397-401693 [Haemophilus aegyptius]
MNKISPLGSNWNEFEQQIFNEEEIRESNLRVALIKELITSRQQLGISQKQLETLSGVKQPMIARIEKGQTNPQLETLLKL
LAPLGKTLSIVPLRVKNA

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0Y7JUP0

Antitoxin

Source ID Structure

References