Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 47497..48128 Replicon chromosome
Accession NZ_LS483429
Organism Haemophilus aegyptius strain NCTC8502

Toxin (Protein)


Gene name vapC Uniprot ID Q4QLW0
Locus tag DQN49_RS00235 Protein ID WP_005651560.1
Coordinates 47730..48128 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q4QLV9
Locus tag DQN49_RS00230 Protein ID WP_005648011.1
Coordinates 47497..47730 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN49_RS00205 42976..44178 - 1203 WP_006995609.1 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate--cysteine ligase CoaBC -
DQN49_RS00210 44342..45007 + 666 WP_013527272.1 DNA repair protein RadC -
DQN49_RS00215 45221..45457 + 237 WP_006995608.1 50S ribosomal protein L28 -
DQN49_RS00220 45469..45639 + 171 WP_005613503.1 50S ribosomal protein L33 -
DQN49_RS00225 45986..47350 + 1365 WP_006995606.1 diaminobutyrate--2-oxoglutarate transaminase -
DQN49_RS00230 47497..47730 + 234 WP_005648011.1 type II toxin-antitoxin system antitoxin VapB2 Antitoxin
DQN49_RS00235 47730..48128 + 399 WP_005651560.1 tRNA(fMet)-specific endonuclease VapC Toxin
DQN49_RS00240 48148..49683 + 1536 WP_006995605.1 L-2,4-diaminobutyrate decarboxylase -
DQN49_RS00245 49926..50741 + 816 WP_005648023.1 DNA-formamidopyrimidine glycosylase -
DQN49_RS00250 50815..51837 - 1023 WP_065246977.1 outer membrane-stress sensor serine endopeptidase DegS -
DQN49_RS00255 51838..52956 - 1119 WP_006995603.1 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase RibD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 15115.46 Da        Isoelectric Point: 8.0514

>T292556 WP_005651560.1 NZ_LS483429:47730-48128 [Haemophilus aegyptius]
VLKYMLDTNIVIYVIKRRPLEILSRFNQNAGKMCVSSITVAELYYGAEKSEYPERNIAVIEDFLSRLTILDYQPKHAAHF
GNIKAELSKQGKLIGENDIHIAAHARSEGLILVSNNLREFERVIALRTENWV

Download         Length: 399 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8880.98 Da        Isoelectric Point: 4.4013

>AT292556 WP_005648011.1 NZ_LS483429:47497-47730 [Haemophilus aegyptius]
MIEASVFMTNRSQAVRLPAEVRFSEEIKKLSVRVSGSDRILSPLNQSWDSFFLNDQAVSDDFMNEREIAFQPEREAL

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q4QLW0

Antitoxin

Source ID Structure
AlphaFold DB A0A806DGS0

References