Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 711839..712485 Replicon chromosome
Accession NZ_LS483426
Organism Kingella kingae strain NCTC10529

Toxin (Protein)


Gene name VapC1 Uniprot ID F5S4I4
Locus tag DQN52_RS03890 Protein ID WP_003785163.1
Coordinates 712078..712485 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name VapB1 Uniprot ID F5S4I3
Locus tag DQN52_RS03885 Protein ID WP_003785161.1
Coordinates 711839..712081 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN52_RS03860 707236..707979 + 744 WP_003785156.1 IS110 family transposase -
DQN52_RS03865 708244..708327 + 84 Protein_717 IS5/IS1182 family transposase -
DQN52_RS03875 708763..709572 - 810 WP_003785159.1 hypothetical protein -
DQN52_RS03880 709659..711698 - 2040 WP_003785160.1 excinuclease ABC subunit B -
DQN52_RS03885 711839..712081 + 243 WP_003785161.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
DQN52_RS03890 712078..712485 + 408 WP_003785163.1 type II toxin-antitoxin system VapC family toxin Toxin
DQN52_RS03895 712545..713042 - 498 WP_003785166.1 thiol peroxidase -
DQN52_RS03900 713136..713636 - 501 WP_003785168.1 hypothetical protein -
DQN52_RS03905 713727..714905 - 1179 WP_003785170.1 phosphoglycerate kinase -
DQN52_RS03910 714985..715617 - 633 WP_003791386.1 pyridoxamine 5'-phosphate oxidase -
DQN52_RS03915 715837..717087 + 1251 WP_003785176.1 glutamyl-tRNA reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-125)

Antitoxin

SpoVT-AbrB domain

(6-40)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15241.45 Da        Isoelectric Point: 6.8791

>T292554 WP_003785163.1 NZ_LS483426:712078-712485 [Kingella kingae]
MMYLLDTNILIYIQKNNPPTVREKINNLPNSAQLVMSFVTYAELLKGTYGSQNLEKAQANLNALTRIISVLPSHEAMPEH
YANWANQLKKQGKPIGNNDLWIAAHALAVGAVLVTHNTKEFSRINNLQLEDWVEE

Download         Length: 408 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9242.32 Da        Isoelectric Point: 4.1964

>AT292554 WP_003785161.1 NZ_LS483426:711839-712081 [Kingella kingae]
MLTKVFQSGNSQAVRIPMNFRFDVDTVEIFRTENGDVVLRSPKPQNRGDELFAILQQFDDDFIATVEARDNEPPQEREVL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB F5S4I4

Antitoxin

Source ID Structure
AlphaFold DB F5S4I3

References