Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 3240671..3241332 Replicon chromosome
Accession NZ_LS483424
Organism Bordetella parapertussis strain NCTC10520

Toxin (Protein)


Gene name vapC Uniprot ID Q7WAH5
Locus tag DQO06_RS15245 Protein ID WP_003812073.1
Coordinates 3240907..3241332 (+) Length 142 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag DQO06_RS15240 Protein ID WP_003812071.1
Coordinates 3240671..3240910 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO06_RS15205 3235706..3236509 - 804 WP_003812055.1 bacteriocin family protein -
DQO06_RS15210 3236506..3237552 - 1047 WP_010928022.1 Dyp-type peroxidase -
DQO06_RS15215 3237630..3238190 - 561 WP_010928021.1 DUF488 domain-containing protein -
DQO06_RS15220 3238187..3238420 - 234 WP_033447224.1 DUF2945 domain-containing protein -
DQO06_RS15225 3238501..3239013 - 513 WP_003812062.1 redoxin domain-containing protein -
DQO06_RS15230 3239072..3239617 - 546 WP_010928020.1 peroxidase-related enzyme -
DQO06_RS15235 3239755..3240597 + 843 WP_010928019.1 AraC family transcriptional regulator -
DQO06_RS15240 3240671..3240910 + 240 WP_003812071.1 Arc family DNA-binding protein Antitoxin
DQO06_RS15245 3240907..3241332 + 426 WP_003812073.1 PIN domain-containing protein Toxin
DQO06_RS15250 3241442..3241906 + 465 WP_003812075.1 MarR family transcriptional regulator -
DQO06_RS15255 3242004..3243509 - 1506 WP_010928018.1 tripartite tricarboxylate transporter permease -
DQO06_RS15260 3244008..3244520 + 513 WP_010928017.1 hypothetical protein -
DQO06_RS15265 3244541..3245518 - 978 WP_003812083.1 tripartite tricarboxylate transporter substrate binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-121)

Antitoxin

Arc-like DNA binding domain

(9-46)


Sequences

Toxin        


Download         Length: 142 a.a.        Molecular weight: 14811.22 Da        Isoelectric Point: 6.3704

>T292553 WP_003812073.1 NZ_LS483424:3240907-3241332 [Bordetella parapertussis]
MILLDTDVLLEPLRPAPDPAVAAWLDAQHVETLYLAAPGAAEIQLGLARLPRGKRAEALRHEFERRVLPLFMGHVLPFDT
AAADAYAAVMMRAAAAGHALCAIDGCIAAIATAHGLAIATRHPARFEAAGLAAVDPWHAAA

Download         Length: 426 bp

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8561.78 Da        Isoelectric Point: 11.5658

>AT292553 WP_003812071.1 NZ_LS483424:3240671-3240910 [Bordetella parapertussis]
VSSITVRNVPEEVHRALRVRAATHGRSTEAEIRAILENAVLPDGRVKLGTLLSHIGRGARGMDLTIERNPAPARPASFE

Download         Length: 240 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7WAH5

Antitoxin

Source ID Structure

References