Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpA-brnA/BrnT_toxin-BrnA
Location 2654233..2654764 Replicon chromosome
Accession NZ_LS483424
Organism Bordetella parapertussis strain NCTC10520

Toxin (Protein)


Gene name shpA Uniprot ID K0MH61
Locus tag DQO06_RS12410 Protein ID WP_003812626.1
Coordinates 2654233..2654499 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID K0MF02
Locus tag DQO06_RS12415 Protein ID WP_003816743.1
Coordinates 2654486..2654764 (+) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO06_RS12385 2649360..2649632 + 273 WP_003812615.1 hypothetical protein -
DQO06_RS12390 2649671..2650381 - 711 WP_003812617.1 aquaporin Z -
DQO06_RS12395 2650492..2651124 - 633 WP_003812619.1 PAS domain-containing protein -
DQO06_RS12400 2651521..2652399 + 879 WP_041937387.1 tripartite tricarboxylate transporter substrate binding protein -
DQO06_RS12405 2652461..2654002 + 1542 WP_010928296.1 M81 family metallopeptidase -
DQO06_RS12410 2654233..2654499 + 267 WP_003812626.1 BrnT family toxin Toxin
DQO06_RS12415 2654486..2654764 + 279 WP_003816743.1 BrnA antitoxin family protein Antitoxin
DQO06_RS12425 2655058..2655714 - 657 WP_010928295.1 phosphoribosylanthranilate isomerase -
DQO06_RS12430 2655729..2657396 - 1668 WP_010928294.1 TRAP transporter large permease subunit -
DQO06_RS12435 2657399..2658028 - 630 WP_010928293.1 TRAP transporter small permease subunit -
DQO06_RS12440 2658240..2659334 - 1095 WP_003812637.1 TRAP transporter substrate-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(12-86)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10037.47 Da        Isoelectric Point: 7.9923

>T292552 WP_003812626.1 NZ_LS483424:2654233-2654499 [Bordetella parapertussis]
MDITYDPAKNDKNIADRGLSFELVCGFEWASALVVEDTRQVYAETRYQALGKIDGRLHMVVFTVRGESLRIISLRKANAR
EVARYEKA

Download         Length: 267 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10412.89 Da        Isoelectric Point: 10.5548

>AT292552 WP_003816743.1 NZ_LS483424:2654486-2654764 [Bordetella parapertussis]
MKKPDPEKIDRDNPEWTDAEFRRAKPAAEVLPESVHAMLGIRRRGPQKTPTKQVVTIRLSPDVVEAFKASGTGWQTRVDA
ALRDWLKTHQPG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB K0MH61

Antitoxin

Source ID Structure
AlphaFold DB K0MF02

References