Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 1363905..1364541 Replicon chromosome
Accession NZ_LS483424
Organism Bordetella parapertussis strain NCTC10520

Toxin (Protein)


Gene name hicA Uniprot ID Q7W5Z1
Locus tag DQO06_RS06400 Protein ID WP_010928914.1
Coordinates 1364359..1364541 (-) Length 61 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID Q7W5Z0
Locus tag DQO06_RS06395 Protein ID WP_010928915.1
Coordinates 1363905..1364297 (-) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQO06_RS06370 1359561..1359987 - 427 Protein_1251 OB-fold domain-containing protein -
DQO06_RS06375 1359991..1361163 - 1173 WP_010928918.1 thiolase domain-containing protein -
DQO06_RS06380 1361230..1361589 - 360 WP_010928917.1 hypothetical protein -
DQO06_RS06385 1361624..1362598 - 975 WP_010928916.1 tripartite tricarboxylate transporter substrate binding protein -
DQO06_RS06390 1362723..1363632 + 910 Protein_1255 LysR family transcriptional regulator -
DQO06_RS06395 1363905..1364297 - 393 WP_010928915.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
DQO06_RS06400 1364359..1364541 - 183 WP_010928914.1 type II toxin-antitoxin system HicA family toxin Toxin
DQO06_RS06410 1365090..1366310 - 1221 WP_010928912.1 ISL3-like element IS1001 family transposase -
DQO06_RS06420 1366886..1368073 - 1188 WP_010928911.1 MFS transporter -
DQO06_RS06425 1368291..1368968 - 678 WP_010928910.1 HAD-IA family hydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 1365090..1366310 1220


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(3-59)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-127)


Sequences

Toxin        


Download         Length: 61 a.a.        Molecular weight: 6572.69 Da        Isoelectric Point: 10.9062

>T292549 WP_010928914.1 NZ_LS483424:c1364541-1364359 [Bordetella parapertussis]
MDGKELIKQLERSGWTLRSVKGSHHVFAHPDRPGHISVPHPKKDLGIGLLNSILKAAGLK

Download         Length: 183 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 14058.82 Da        Isoelectric Point: 4.2876

>AT292549 WP_010928915.1 NZ_LS483424:c1364297-1363905 [Bordetella parapertussis]
VKYPIAIEPGSDTRAWGVVVPDLPGCFSAADEGIDQAIENAKEAIELWIETAIDSGAPIPAATNIANHQANPEFANWIWA
IADVDPAVLDETVERVNITIPRRILKRLDDRARAAGESRSSYIAHLAMTA

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB Q7W5Z1

Antitoxin

Source ID Structure
AlphaFold DB Q7W5Z0

References