Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 4279501..4281077 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name hipA Uniprot ID A0A1B7JUB5
Locus tag DQN80_RS19610 Protein ID WP_068908749.1
Coordinates 4279501..4280820 (-) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1B7JUC4
Locus tag DQN80_RS19615 Protein ID WP_068437935.1
Coordinates 4280820..4281077 (-) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS19600 4275436..4278483 - 3048 WP_082913019.1 formate dehydrogenase-N subunit alpha -
DQN80_RS19605 4278659..4279489 + 831 WP_068908748.1 formate dehydrogenase accessory sulfurtransferase FdhD -
DQN80_RS19610 4279501..4280820 - 1320 WP_068908749.1 type II toxin-antitoxin system HipA family toxin Toxin
DQN80_RS19615 4280820..4281077 - 258 WP_068437935.1 helix-turn-helix domain-containing protein Antitoxin
DQN80_RS19620 4281235..4282599 - 1365 WP_068437934.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
DQN80_RS19625 4282747..4284396 - 1650 WP_068437931.1 membrane protein insertase YidC -
DQN80_RS19630 4284399..4284659 - 261 WP_068437928.1 membrane protein insertion efficiency factor YidD -
DQN80_RS19635 4284623..4284982 - 360 WP_073889908.1 ribonuclease P protein component -
DQN80_RS19640 4285004..4285147 - 144 WP_068437925.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-65)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 50212.38 Da        Isoelectric Point: 5.6741

>T292546 WP_068908749.1 NZ_LS483422:c4280820-4279501 [Providencia heimbachae]
MATLHVYMNGYLVGEFIRLSTGAHQFKYDIHWLETPGARPISLSMPLQHQEYKGDEVYNFFDNLLPDNSEIRKRVVRRYR
AESTQPFDLLSKIGQDSVGALQLVPNELNVSDIKKIEYRPLSDEALEKVLNGYKSDSPLGMIEEVDDFRISIAGAQEKTA
LLYFNDQWYLPLRTTPTTHIIKLPIGEIQSHSHTLDMSDSVENEFLCLLIAAEFGFDVPKCTIINVGETKALAVERFDRK
FSADNAWIMRLPQEDFCQTLNVLSENKYQKDGGPGIYDIMTYLLGSINTEKDRYQFMKSQVLFWLLAATDGHAKNFSLFI
EPEGRYKLTPFYDILSVYPVFGGKGLNPREAKLAMSLKGTKGNKDKIEQIFPRHFFATAKAVGFDRTEMERIFIEFDEQM
ESVITKVRDQLPADFPEHIANSILSGLQSKAIRLKKGWD

Download         Length: 1320 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9669.90 Da        Isoelectric Point: 9.6898

>AT292546 WP_068437935.1 NZ_LS483422:c4281077-4280820 [Providencia heimbachae]
MKVTNTRQLSAYMKDVRETKKLSQSKVASKVGIRQDTVSNFELSPDSTKLETFFKILSALNLELDIKPRNESGSSNTDSG
WKEEW

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JUB5

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JUC4

References