Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relB-yefM/YoeB-RelB
Location 4206926..4207433 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name relB Uniprot ID A0A4D7JI57
Locus tag DQN80_RS19285 Protein ID WP_068438114.1
Coordinates 4207173..4207433 (+) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1B7JUP1
Locus tag DQN80_RS19280 Protein ID WP_068438117.1
Coordinates 4206926..4207180 (+) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS19255 4202475..4203284 + 810 WP_197713314.1 3-deoxy-8-phosphooctulonate synthase -
DQN80_RS19260 4203367..4204116 + 750 WP_068908694.1 3-deoxy-manno-octulosonate cytidylyltransferase -
DQN80_RS19265 4204116..4205039 + 924 WP_068908695.1 KpsF/GutQ family sugar-phosphate isomerase -
DQN80_RS19270 4205151..4206176 + 1026 WP_068908697.1 UDP-glucose 4-epimerase GalE -
DQN80_RS19275 4206337..4206840 + 504 WP_068438120.1 tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL -
DQN80_RS19280 4206926..4207180 + 255 WP_068438117.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
DQN80_RS19285 4207173..4207433 + 261 WP_068438114.1 Txe/YoeB family addiction module toxin Toxin
DQN80_RS19290 4207448..4208269 - 822 WP_068438112.1 serine O-acetyltransferase -
DQN80_RS19295 4208279..4209313 - 1035 WP_068908699.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
DQN80_RS19300 4209313..4209789 - 477 WP_068438107.1 protein-export chaperone SecB -
DQN80_RS19305 4209861..4210298 - 438 WP_068438104.1 rhodanese-like domain-containing protein -
DQN80_RS19310 4210732..4212024 + 1293 WP_068438101.1 murein hydrolase activator EnvC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(7-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10422.83 Da        Isoelectric Point: 8.8207

>T292545 WP_068438114.1 NZ_LS483422:4207173-4207433 [Providencia heimbachae]
MSRFLAWTDQAWEDYLYWQTQDKKTLKRINKLIDDTKRTPFYGIGKPEPLKENLAGFWSRRIDETNRLIYSVDDTNLTIV
ACRYHY

Download         Length: 261 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9548.87 Da        Isoelectric Point: 7.0113

>AT292545 WP_068438117.1 NZ_LS483422:4206926-4207180 [Providencia heimbachae]
MKTISFSDARNNLKAVLDRVVDDADTTIITRRDSEDAVVMSLEYYNSLMETIYLLRSPANAEHLNKSIAQFKAGKAKKRE
LINE

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A4D7JI57

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JUP1

References