Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4002947..4003484 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name relE Uniprot ID A0A1B7JVG2
Locus tag DQN80_RS18265 Protein ID WP_068908568.1
Coordinates 4002947..4003240 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A1B7JVD7
Locus tag DQN80_RS18270 Protein ID WP_068908569.1
Coordinates 4003230..4003484 (-) Length 85 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS18235 3998441..3999721 - 1281 WP_068908562.1 N-acetylmuramoyl-L-alanine amidase AmiB -
DQN80_RS18240 3999736..4000200 - 465 WP_068439823.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex ATPase subunit type 1 TsaE -
DQN80_RS18245 4000551..4001708 + 1158 WP_068908566.1 tRNA epoxyqueuosine(34) reductase QueG -
DQN80_RS18265 4002947..4003240 - 294 WP_068908568.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
DQN80_RS18270 4003230..4003484 - 255 WP_068908569.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DQN80_RS18275 4003606..4004148 - 543 WP_068908571.1 oligoribonuclease -
DQN80_RS18280 4004273..4005325 + 1053 WP_068908573.1 small ribosomal subunit biogenesis GTPase RsgA -
DQN80_RS18285 4005521..4006420 + 900 WP_197713312.1 phosphatidylserine decarboxylase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-83)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-73)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11444.36 Da        Isoelectric Point: 10.3916

>T292544 WP_068908568.1 NZ_LS483422:c4003240-4002947 [Providencia heimbachae]
MIFNIEFDERALKEWNKLDSSVREQFKKKLKKLQTNPYIESARLNGEQSNCYKIKLRSSGYRLVYQIIDSEIVIFVIAIG
KRDAQKAYKVANIRLTK

Download         Length: 294 bp

Antitoxin


Download         Length: 85 a.a.        Molecular weight: 9663.07 Da        Isoelectric Point: 4.8538

>AT292544 WP_068908569.1 NZ_LS483422:c4003484-4003230 [Providencia heimbachae]
MSTIQIRVDEQLKKDAYQAFEKLNLSPSDALRLFLRYVAENEKLPFSEVSIVVSESDDDDAILAVVRERLKKPAKRIRVN
VDDL

Download         Length: 255 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JVG2

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JVD7

References