Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1477187..1477844 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name cptA Uniprot ID A0A1B7JKI9
Locus tag DQN80_RS06435 Protein ID WP_068445594.1
Coordinates 1477434..1477844 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A1B7JKJ9
Locus tag DQN80_RS06430 Protein ID WP_068445596.1
Coordinates 1477187..1477453 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS06415 1472374..1475250 + 2877 WP_068909905.1 aminomethyl-transferring glycine dehydrogenase -
DQN80_RS06420 1475317..1475937 - 621 WP_068445600.1 HD domain-containing protein -
DQN80_RS06425 1475949..1476935 - 987 WP_068909907.1 tRNA-modifying protein YgfZ -
DQN80_RS06430 1477187..1477453 + 267 WP_068445596.1 FAD assembly factor SdhE Antitoxin
DQN80_RS06435 1477434..1477844 + 411 WP_068445594.1 hypothetical protein Toxin
DQN80_RS06440 1477902..1478420 - 519 WP_068909908.1 flavodoxin FldB -
DQN80_RS06445 1478560..1479462 + 903 WP_068445591.1 site-specific tyrosine recombinase XerD -
DQN80_RS06450 1479482..1480183 + 702 WP_068909910.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
DQN80_RS06455 1480192..1481925 + 1734 WP_068909912.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-133)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 15619.56 Da        Isoelectric Point: 10.7186

>T292540 WP_068445594.1 NZ_LS483422:1477434-1477844 [Providencia heimbachae]
VVLWKSNLAISWKTQLFSTCIHGVIGAFVLIAPWVSETSMIWLPLLVVIVASWAKSQKNISKIKGIVVLVNGNKVQWKKN
EWYIDKAPWRSRFGILLTLSALQGKPKKIHLWIAKDTVSEENWRNLNQLLLQYPDI

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10542.03 Da        Isoelectric Point: 4.6786

>AT292540 WP_068445596.1 NZ_LS483422:1477187-1477453 [Providencia heimbachae]
MDIENKARIHWACRRGMRELDISIMPFFEYEYDGLSSEDKQTFVNLLECADPDLFNWLMNHGRPDDDKLFYMVKLIQEKN
KNRGPVEI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JKI9

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JKJ9

References