Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 890249..890891 Replicon chromosome
Accession NZ_LS483422
Organism Providencia heimbachae strain NCTC12003

Toxin (Protein)


Gene name Hha Uniprot ID A0A1B7JP77
Locus tag DQN80_RS03845 Protein ID WP_068439370.1
Coordinates 890249..890452 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID A0A1B7JPC0
Locus tag DQN80_RS03850 Protein ID WP_068439372.1
Coordinates 890523..890891 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DQN80_RS03820 886214..886552 + 339 WP_068909458.1 P-II family nitrogen regulator -
DQN80_RS03825 886563..887846 + 1284 WP_068439364.1 ammonium transporter AmtB -
DQN80_RS03830 887961..888827 - 867 WP_068909460.1 acyl-CoA thioesterase II -
DQN80_RS03835 889148..889606 + 459 WP_068439368.1 YbaY family lipoprotein -
DQN80_RS03845 890249..890452 - 204 WP_068439370.1 hemolysin expression modulator Hha Toxin
DQN80_RS03850 890523..890891 - 369 WP_068439372.1 Hha toxicity modulator TomB Antitoxin
DQN80_RS03855 891537..892907 - 1371 WP_068909462.1 murein transglycosylase D -
DQN80_RS03860 892989..893744 - 756 WP_068439376.1 hydroxyacylglutathione hydrolase -
DQN80_RS03865 893778..894506 + 729 WP_068439378.1 methyltransferase domain-containing protein -
DQN80_RS03870 894517..894987 - 471 WP_068439381.1 ribonuclease HI -
DQN80_RS03875 895047..895808 + 762 WP_068439382.1 DNA polymerase III subunit epsilon -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8161.50 Da        Isoelectric Point: 6.9775

>T292539 WP_068439370.1 NZ_LS483422:c890452-890249 [Providencia heimbachae]
MTKFDYLMRLRKCTTIETLERVIEKNKYELSEDELELFYSAADHRLAELTMNKLYDKIPPSVWKFVR

Download         Length: 204 bp

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14181.08 Da        Isoelectric Point: 4.3945

>AT292539 WP_068439372.1 NZ_LS483422:c890891-890523 [Providencia heimbachae]
MDEYSPKKHDIAELKYLCNSLNRDAILSLQKTNTHWINDLSSQQSANLNELIEHIAAFVWRFKIKYPKENLVISLVEEYL
DETYDLFGSPVITLSEIIDWESMNQNLVSVLEDDLKCLTSKT

Download         Length: 369 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B7JP77

Antitoxin

Source ID Structure
AlphaFold DB A0A1B7JPC0

References